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Approximately 5% of all women affected by vulvar LS will develop vulvar squamous cell carcinoma. Topical treatment is safe but less effective resulting in chronic course in most patients, who suffer from persistent itching and pain. In severe cases of therapy\u2010resistant LS, there is no adequate treatment. Fat grafting is a novel regenerative therapy to reduce dermal fibrosis. The therapeutic effect of adipose tissue grafts for LS is already investigated in various pioneering studies. This review provides an overview of these studies and the putative mechanisms\u2010of\u2010action of fat grafting to treat LS.<\/jats:p>","DOI":"10.1111\/exd.14561","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T20:54:57Z","timestamp":1647032097000},"page":"689-699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Autologous lipoaspirate as a new treatment of vulvar lichen sclerosus: A review on literature"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5336-1967","authenticated-orcid":false,"given":"Nanouk","family":"van der Sluis","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery University of Groningen, University Medical Center Groningen  Groningen The Netherlands"},{"name":"Department of Plastic\u2010, Reconstructive\u2010 and Hand Surgery Medisch Spectrum Twente  Enschede The 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