{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:53:48Z","timestamp":1791197628763,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is a strong interaction between the immunological and nervous system in the skin. Lesions that are physically disfiguring and chronically relapsing have a high impact on quality of life (QoL) and can result in the emergence of psychiatric disorders. The literature data confirm a higher prevalence of psychiatric disorders in patients with psoriasis, hidradenitis suppurativa (HS) and atopic dermatitis (AD), but such data are compromised by low\u2010quality evidence due to methodological heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The primary aim was to analyse the prevalence of psychiatric comorbidities in a group of psoriasis, AD and HS patients compared with a control group. The secondary aims were to evaluate the impact of psychiatric comorbidities on the disease development, severity, flare\u2010ups and QoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 59 cases and 64 controls were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Generalized anxiety disorder and depressive disorder with anxious distress were found to be risk factors for AD. Age, smoking and substance\u2010related disorder showed a specific association with HS. Major depressive disorder showed a specific association with dermatology life quality index (DLQI) and all the above disease flare\u2010ups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Atopic dermatitis, psoriasis and HS are associated with psychiatric disorders. A psychodermatological approach improves outcomes in terms of QoL, disease flare\u2010ups and long\u2010term management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/exd.14563","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T01:22:27Z","timestamp":1647220947000},"page":"956-961","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Impact of psychiatric comorbidities in psoriasis, hidradenitis suppurativa and atopic dermatitis: The importance of a psychodermatological approach"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1463-0017","authenticated-orcid":false,"given":"Michela","family":"Iannone","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Janowska","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Panduri","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Morganti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine Section of Statistics University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Davini","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Romanelli","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Dini","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2008.00166.x"},{"key":"e_1_2_11_3_1","first-page":"38","article-title":"Psychoneuroimmunology and the Skin","volume":"96","author":"Honeyman JF","year":"2016","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.530"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/ddg.12957","article-title":"Stressed skin?\u2013a molecular psychosomatic update on stress\u2010causes and effects in dermatologic diseases","volume":"14","author":"Peters EM","year":"2016","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61128-3"},{"key":"e_1_2_11_7_1","first-page":"139","article-title":"Patients\u2019 beliefs about psoriasis","volume":"56","author":"Savin JA","year":"1970","journal-title":"Trans St Johns Hosp Dermatol Soc"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1993.tb02790.x"},{"key":"e_1_2_11_9_1","first-page":"36","article-title":"Psoriasis and associated psychiatric disorders: a systematic review on etiopathogenesis and clinical correlation","volume":"9","author":"Ferreira BI","year":"2016","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05071.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2021.1933929"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.03.017"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2019.02.026"},{"key":"e_1_2_11_14_1","unstructured":"Experience Project Website.I have hidradenitis suppurativa. 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