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Biomarkers for cardiovascular (CV) risk stratification in psoriasis are lacking, and the effects of psoriasis biologics on CV risk reduction remain unclear. The goal of this study was to identify biomarkers of CV risk in psoriasis blood that are reduced by ustekinumab. We quantified 276 inflammatory and CV\u2010related serum proteins with Olink's multiplex assay in 10 psoriasis patients (vs. 18 healthy controls) and after 12\u2009weeks of ustekinumab treatment. For each protein down\u2010regulated after treatment, the literature was reviewed for studies assessing the protein's association with CVD. Data were collected from each study to calculate CV risk thresholds for each protein, which were compared with protein levels in psoriasis patients before and after treatment. Our results showed that 43 out of 276 proteins were down\u2010regulated after treatment, 25 of which were initially up\u2010regulated at baseline (vs. controls, all <jats:italic>p<\/jats:italic>\u2010values \u22640.1). 8 down\u2010regulated proteins were initially elevated above thresholds associated with enhanced CV risk in the literature (myeloperoxidase, C\u2010X\u2010C motif chemokine 10, E\u2010selectin, interleukin\u20106, cystatin B, von Willebrand factor, tumor necrosis factor receptor 1 and N\u2010terminal prohormone brain natriuretic peptide). Treatment lowered these proteins to below their risk thresholds, except for IL\u20106, which was lowered but remained at its risk threshold despite successful psoriasis skin treatment. In summary, 12\u2009weeks of ustekinumab treatment reduced serum proteins present at levels associated with CV risk in psoriasis patients. Further studies can evaluate these proteins as potential ustekinumab\u2010modulated biomarkers of CV risk in psoriasis and the impact of ustekinumab on CV risk reduction.<\/jats:p>","DOI":"10.1111\/exd.14582","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T08:08:46Z","timestamp":1651046926000},"page":"1341-1351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Ustekinumab reduces serum protein levels associated with cardiovascular risk in psoriasis vulgaris"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4109-9820","authenticated-orcid":false,"given":"Merav","family":"Koschitzky","sequence":"first","affiliation":[{"name":"Laboratory of Investigative Dermatology The Rockefeller University  New York New York USA"},{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1405-2955","authenticated-orcid":false,"given":"Kristina","family":"Navrazhina","sequence":"additional","affiliation":[{"name":"Laboratory of Investigative Dermatology The Rockefeller University  New York New York USA"},{"name":"Weill Cornell\/Rockefeller\/Sloan Kettering Tri\u2010Institutional MD\u2010PhD Program Weill Cornell University  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6649-3755","authenticated-orcid":false,"given":"Michael S.","family":"Garshick","sequence":"additional","affiliation":[{"name":"Center for the Prevention of Cardiovascular Disease and Leon H. 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