{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:56Z","timestamp":1787014196580,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Photodynamic therapy (PDT) with 5\u2010aminolevulinic acid hydrochloride (ALA) is an established method for the management of AK. PD P 506 A (brand name Alacare\u00ae) is an approved medicinal product for the treatment of AK located on scalp and face. It is a self\u2010adhesive, light\u2010proof patch loaded with 5\u2010ALA HCl and was developed for easy handling. AK located on arms, hands or trunk do not respond as well to ALA\u2010PDT as AK lesions on the head do. It has been reported that occlusion during ALA incubation can improve clinical outcome after ALA\u2010PDT for AK on hands and arms. We present the results of a first explorative pilot study involving 20 participants with a total of 145 treated (122 evaluable) AK lesions. The trial investigated the conduct of two ALA\u2010PDTs within 1\u20132\u2009weeks and involved all severity grades of AK. The model\u2010based percentage of complete clearance on lesion\u2010basis was estimated being 78.0% (95%\u2010CI: [64.6%, 87.3%]), and the by\u2010participant calculation (patient\u2010based clearance) led to similar results (78.7% with a 95%\u2010CI of [67.0%, 90.3%]). The treatment was well tolerated. Local reactions during ALA patch incubation were rare whereas nearly all patients showed the expected reactions during or after the illumination, primarily erythema and pain. The study results indicate that two PD P 506 A\u2010PDT sessions 1\u20132\u2009weeks apart are an efficacious treatment for AK on hands and arms. Especially mild but also moderate lesions responded very well to PDT treatment involving ALA incubation under occlusion.<\/jats:p>","DOI":"10.1111\/exd.14606","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T23:54:25Z","timestamp":1652399665000},"page":"1385-1391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>5\u2010ALA<\/scp>\n                    loaded self\u2010adhesive\n                    <scp>patch\u2010PDT<\/scp>\n                    is effective and safe in the treatment of actinic keratoses on hands and arms"],"prefix":"10.1111","volume":"31","author":[{"given":"Jon Chim","family":"Bai\u2010Habelski","sequence":"first","affiliation":[{"name":"MVZ Dermatologisches Zentrum Bonn GmbH  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Ko","sequence":"additional","affiliation":[{"name":"MVZ Dermatologisches Zentrum Bonn GmbH  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Ortland","sequence":"additional","affiliation":[{"name":"Forschungsdock GmbH  Schenefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4805-3948","authenticated-orcid":false,"given":"Marcus","family":"Stocker","sequence":"additional","affiliation":[{"name":"Photonamic GmbH &amp; Co. 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