{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:36:17Z","timestamp":1790800577764,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["BE2021723"],"award-info":[{"award-number":["BE2021723"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970941"],"award-info":[{"award-number":["81970941"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["PAPD,2018\u201087"],"award-info":[{"award-number":["PAPD,2018\u201087"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oral lichen planus (OLP) is a T cell\u2013mediated, chronic inflammatory disease. CD4<jats:sup>+<\/jats:sup> T\u2010cell infiltration plays a crucial role in the pathogenesis of OLP. Fibroblasts are activated under pathological conditions and perform various functions. This study was designed to explore the immune activation and biological functions of OLP fibroblasts on CD4<jats:sup>+<\/jats:sup> T cells. We detected the expression of fibroblast activation protein\u2010alpha (FAP\u2010\u03b1) in the oral tissues of patients with OLP and healthy controls using immunohistochemistry. Furthermore, expression of FAP\u2010\u03b1 and C\u2010C motif chemokine ligand 5 (CCL5) in fibroblasts isolated from oral tissues of patients with OLP and healthy controls was assayed by quantitative PCR, Western blotting and enzyme\u2010linked immunosorbent assay. Moreover, we assessed the effects of fibroblasts on CD4<jats:sup>+<\/jats:sup> T\u2010cell proliferation, apoptosis and migration using flow cytometry and Transwell assays. We found that FAP\u2010\u03b1 expression in the oral tissues of patients with OLP was significantly higher than that in healthy controls. FAP\u2010\u03b1 and CCL5 expression levels were significantly upregulated in OLP fibroblasts. Moreover, OLP fibroblasts promoted CD4<jats:sup>+<\/jats:sup> T\u2010cell proliferation and migration and inhibited CD4<jats:sup>+<\/jats:sup> T cell apoptosis. In summary, our findings indicate that OLP fibroblasts are immunologically activated and induce CD4<jats:sup>+<\/jats:sup> T\u2010cell infiltration in OLP.<\/jats:p>","DOI":"10.1111\/exd.14613","type":"journal-article","created":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T13:18:55Z","timestamp":1653225535000},"page":"1421-1430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["<scp>FAP<\/scp>\u2010\u03b1<sup>+<\/sup> immunofibroblasts in oral lichen planus promote <scp>CD4<\/scp><sup>+<\/sup> T\u2010cell infiltration via <scp>CCL5<\/scp> secretion"],"prefix":"10.1111","volume":"31","author":[{"given":"Yuyao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Oral Mucosal Diseases The Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Province Key Laboratory of Oral Diseases Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kefan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral Mucosal Diseases The Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Province Key Laboratory of Oral Diseases Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juehua","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Oral Mucosal Diseases The Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Province Key Laboratory of Oral Diseases Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Oral Mucosal Diseases The Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Province Key Laboratory of Oral Diseases Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengna","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Mucosal Diseases The Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Province Key Laboratory of Oral Diseases Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4759-5625","authenticated-orcid":false,"given":"Yuan","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Oral Mucosal Diseases The Affiliated Stomatological Hospital of Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Province Key Laboratory of Oral Diseases Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13323"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13704"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12885"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-016-1667-2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12405"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.03.012"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12928"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14203"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00629"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13244"},{"issue":"10","key":"e_1_2_9_12_1","first-page":"703","article-title":"Comparison of Oral lichen planus and systemic lupus erythematosus in interleukins level","volume":"18","author":"Agha\u2010Hosseini F","year":"2015","journal-title":"Arch Iran Med"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12142"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62258-7"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13946"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-018-0934-0"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13344"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2021.01.005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.725169"},{"issue":"4","key":"e_1_2_9_20_1","first-page":"405","article-title":"Cross\u2010talk between CXC chemokine ligand 10\u2010CXC chemokine receptor 3 axis and CC chemokine ligand 17\u2010CC chemokine receptor 4 axis in the pathogenesis of oral lichen planus","volume":"39","author":"Tang N","year":"2021","journal-title":"West China J Stomatol"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00540-z"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1263-7"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.06.029"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1905301116"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00125.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI93555"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.244806"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.05.022"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.03.009"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0524-6"},{"key":"e_1_2_9_32_1","first-page":"1","article-title":"Immune mechanisms in oral lichen planus","volume":"00","author":"El\u2010Howati A","year":"2022","journal-title":"Oral Dis"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04221-8"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28120-2"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13087"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00333"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-021-03612-8"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdtm.2020.02.001"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.12.028"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14049"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2006.00402.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2017.06.024"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.137263"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14613","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.14613","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T08:58:15Z","timestamp":1692694695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/exd.14613"],"URL":"https:\/\/doi.org\/10.1111\/exd.14613","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"2022-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}