{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:09:17Z","timestamp":1774570157663,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T00:00:00Z","timestamp":1655078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>COVID\u201019 morbidity and mortality are driven by poor immune regulation. Narrowband ultraviolet B (NB\u2010UVB) phototherapy is standard of care in a number of immune\u2010dysregulated diseases. To assess the efficacy of NB\u2010UVB phototherapy for improving COVID\u201019 outcomes in high\u2010risk, hospitalized, we developed the Adaptive Photo\u2010Protection Trial. This is a multi\u2010center, prospective, double\u2010blinded, randomized, placebo\u2010controlled trial. The pilot phase results are reported here. Consecutive patients admitted with a positive COVID\u201019 PCR were screened for eligibility. Enrolled subjects were computer randomized 1:1 to NB\u2010UVB or placebo phototherapy. Subjects were treated daily with escalating doses on 27% of their body surface area for up to 8 consecutive days. Primary outcomes were safety and efficacy, defined as persistent or painful erythema and 28\u2010day mortality. Comparisons were made via non\u2010parametric exact tests. Patients in treatment (<jats:italic>n<\/jats:italic>\u00a0=\u00a015) and placebo (<jats:italic>n<\/jats:italic>\u00a0=\u00a015) arms had similar demographics. No adverse events occurred. Twenty eight\u2010day mortality was 13.3% in treatment vs. 33.3% in placebo arms (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.39). NB\u2010UVB phototherapy in hospitalized COVID\u201019 patients was safe. Decreased mortality was observed in treated patients but this was statistically non\u2010significant. Given its low\u2010cost, scalability, and adjunctive nature, NB\u2010UVB has the potential to improve COVID\u201019 outcomes. Continuation of this trial is warranted.<\/jats:p>","DOI":"10.1111\/exd.14617","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T07:59:11Z","timestamp":1653983951000},"page":"1109-1115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pilot phase results of a prospective, randomized controlled trial of narrowband ultraviolet B phototherapy in hospitalized <scp>COVID<\/scp>\u201019 patients"],"prefix":"10.1111","volume":"31","author":[{"given":"Frank H.","family":"Lau","sequence":"first","affiliation":[{"name":"Department of Surgery Louisiana State University Health Sciences Center New Orleans  New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine E.","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Surgery Louisiana State University Health Sciences Center New Orleans  New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Adonecchi","sequence":"additional","affiliation":[{"name":"School of Medicine Louisiana State University Health Sciences Center New Orleans  New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise M.","family":"Danos","sequence":"additional","affiliation":[{"name":"School of Public Health Louisiana State University Health Sciences Center New Orleans  New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew R.","family":"DiNardo","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine Global TB program and William T Shearer Center for Human Immunobiology  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Chugden","sequence":"additional","affiliation":[{"name":"West Jefferson Medical Center  Marrero Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen F.","family":"Castilla","sequence":"additional","affiliation":[{"name":"New York Dermatology Group; Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.616527"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107784"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2019.08.004"},{"key":"e_1_2_10_5_1","article-title":"Vitamin D insufficiency is prevalent in severe COVID\u201019","author":"Lau FH","year":"2020","journal-title":"medRxiv"},{"key":"e_1_2_10_6_1","first-page":"CD015043","article-title":"Vitamin D supplementation for the treatment of COVID\u201019: a living systematic review","volume":"5","author":"Stroehlein JK","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.04.042"},{"issue":"2","key":"e_1_2_10_8_1","first-page":"1165","article-title":"The impact of UV\u2010dose, body surface area exposed and other factors on cutaneous vitamin D synthesis measured as serum 25(OH)D concentration: systematic review and meta\u2010analysis","volume":"38","author":"Jager N","year":"2018","journal-title":"Anticancer Res"},{"key":"e_1_2_10_9_1","volume-title":"StatPearls.","author":"Moore RA","year":"2021"},{"key":"e_1_2_10_10_1","unstructured":"Evaluation of efficacy duration of remission and safety of a light and occlusive patch. therapy for plaque psoriasis. 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