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The aim of our study was to describe epidemiology, clinical\u2010pathological features and treatment strategies of skin cancers in a cohort of patients aged \u226795\u2009years. A total of 116 patients \u226795\u2009years of age presented for the evaluation of 225 skin lesions (mean of 1.94 lesions per patient). The mean age was 97.4\u2009years, 57.8% were women. Most patients had an ECOG score of 3 (49.3%) or 4 (32%). Lesions were mainly located on the head and neck area (74.2%), upper (7.1%) and lower (6,2%) limbs. The majority of patients presented with non\u2010melanoma skin cancers (183\/225; 81.3%), 25\/225 (11.1%) had actinic keratosis, 5 (2.2%) melanoma and 2 (0.9%) atypical fibroxanthoma. Forty\u2010eight lesions (21.3%) were treated with surgery, 58 (25.8%) with radiotherapy. The management of 73 lesion (32.4%) was discussed at the multidisciplinary tumour board meeting. One patient died for the progression of a squamous cell carcinoma; 74 patients died for causes unrelated to skin tumours, 36 are still alive after a mean follow\u2010up of 27.27\u2009months. This cohort study confirms that age is not per se a contraindication for treatment of skin cancers in elderly patients. Our results support the importance of a patient\u2010centred care approach that should take into consideration patient's preferences, comorbidities, compliance and possible adverse events.<\/jats:p>","DOI":"10.1111\/exd.14627","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T15:44:05Z","timestamp":1655739845000},"page":"1554-1562","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Characteristics and management of skin cancers in very elderly patients: A real\u2010world challenge for clinicians"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2180-7984","authenticated-orcid":false,"given":"Michela","family":"Lai","sequence":"first","affiliation":[{"name":"Centro Oncologico ad Alta Tecnologia Diagnostica Azienda Unit\u00e0 Sanitaria Locale \u2010 IRCCS di Reggio Emilia  Reggio Emilia Italy"},{"name":"Department of Dermatology University of 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