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CX\u20105461 is a novel selective inhibitor of RNA polymerase I. Our previous studies have shown that CX\u20105461 has potent anti\u2010inflammatory effects. Here we investigated whether CX\u20105461 could inhibit the development of imiquimod\u2010induced experimental psoriasis in mice. Adult male C57BL\/6 mice were used, and psoriasis\u2010like lesions were induced by topical imiquimod treatment. In vivo, we demonstrated that topical application of CX\u20105461 prevented the development of imiquimod\u2010induced psoriasis, with decreases in keratinocyte proliferation, T\u2010cell infiltration and pathological angiogenesis. CX\u20105461 also reversed existing skin inflammation induced imiquimod and retarded the development of 12\u2010<jats:italic>O<\/jats:italic>\u2010tetradecanoylphorbol\u201013\u2010acetate\u2010induced epidermal hyperplasia and inflammation. In vitro, CX\u20105461 induced cell cycle arrest in keratinocytes, inhibited expressions of interleukin\u201017, interleukin\u201023 receptor and retinoic acid receptor\u2010related orphan receptor\u2010\u03b3t in activated T cells, and reduced angiogenic functions of endothelial cells. In conclusion, CX\u20105461 exhibits therapeutic effects on experimental psoriasis in mice, likely via multiple mechanisms including anti\u2010proliferative, anti\u2010inflammatory and anti\u2010angiogenic activities.<\/jats:p>","DOI":"10.1111\/exd.14682","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T06:45:50Z","timestamp":1664347550000},"page":"91-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Novel <scp>RNA<\/scp> polymerase I inhibitor <scp>CX<\/scp>\u20105461 suppresses imiquimod\u2010induced experimental psoriasis"],"prefix":"10.1111","volume":"32","author":[{"given":"Xiao","family":"Wu","sequence":"first","affiliation":[{"name":"Shandong Key Laboratory of Cardiovascular Proteomics and Department of Geriatric Medicine, Qilu Hospital, Cheeloo College of Medicine Shandong University  Jinan China"},{"name":"Department of Physiology and Pathophysiology, School of Basic 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