{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:27:05Z","timestamp":1787995625799,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sex hormones influence the development and natural course of psoriasis. Here, we examined the effects of female sex hormones, particularly oestrogen, on psoriasis\u2010like dermatitis induced using topical imiquimod in mice that underwent either sham operation (Sham) or ovariectomy (OVX), with (hormone replacement treatment: HRT) or without 17\u03b2\u2010oestradiol targeting the maximum physiological levels. The number of neutrophils in the skin was higher in the order of OVX\u2010, Sham\u2010, and HRT\u2010treated mice. However, no significant difference was detected in the clinical scores among the three groups due to severe erythema and scale in a few mice out of HRT\u2010treated mice in a set of experiments. OVX\u2010 and HRT\u2010treated mice showed increased mRNA levels of interleukin (\n                    <jats:italic>IL<\/jats:italic>\n                    )\u2010\n                    <jats:italic>22<\/jats:italic>\n                    and\n                    <jats:italic>IL\u201023<\/jats:italic>\n                    compared with Sham\u2010treated mice; increased\n                    <jats:italic>IL\u201010<\/jats:italic>\n                    mRNA levels were found in HRT\u2010treated mice, possibly due to an increased proportion of forkhead box P3 (Foxp3)\u2010 and IL\u201010 positive large cells (possibly macrophages). In addition, HRT\u2010treated mice had a more compact stratum corneum with higher expression of loricrin and involucrin than OVX\u2010 and Sham\u2010treated mice. This study suggests that oestrogen has a dual potential in the pathogenesis of psoriasis: suppression of inflammation by enhancing IL\u201010 production and enhancement of inflammation by induction of IL\u201022 and IL\u201023 expression.\n                  <\/jats:p>","DOI":"10.1111\/exd.14688","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T06:04:34Z","timestamp":1665641074000},"page":"203-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Oestrogen inhibits psoriasis\u2010like dermatitis induced by imiquimod in mice in relation to increased\n                    <scp>IL<\/scp>\n                    \u201010 producing cells despite elevated expression of\n                    <scp>IL<\/scp>\n                    \u201022,\n                    <scp>IL<\/scp>\n                    \u201023,\n                    <scp>IL<\/scp>\n                    \u201017\n                    <scp>mRNA<\/scp>"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6064-4252","authenticated-orcid":false,"given":"Keisuke","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Dermatology Dokkyo Medical University Saitama Medical Centre  Koshigaya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6481-9806","authenticated-orcid":false,"given":"Sakiko","family":"Chikazawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dokkyo Medical University Saitama Medical Centre  Koshigaya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4415-1380","authenticated-orcid":false,"given":"Yue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dokkyo Medical University Saitama Medical Centre  Koshigaya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1537-6628","authenticated-orcid":false,"given":"So","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dokkyo Medical University Saitama Medical Centre  Koshigaya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8649-9073","authenticated-orcid":false,"given":"Nao","family":"Ichimasu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dokkyo Medical University Saitama Medical Centre  Koshigaya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8303-6994","authenticated-orcid":false,"given":"Kazumoto","family":"Katagiri","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dokkyo Medical University Saitama Medical Centre  Koshigaya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13854"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.339"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15879"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(85)70188-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2312"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08454.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.5.601"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.03.002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12224"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-006450"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2016.02.009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.11.003"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2006.05.013"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2016.07.015"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199902)42:2<328::Aid-anr16>3.0.Co;2-#"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2018.02.001"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/1547691x.2016.1223768"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194660"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040303"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2018.02.006"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.05.046"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2007.09.007"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13214"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802999"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-017-0415-3"},{"issue":"1","key":"e_1_2_10_27_1","first-page":"53","article-title":"IL\u201010 implications in psoriasis","volume":"2","author":"Al\u2010Robaee AA","year":"2008","journal-title":"Int J Health Sci"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2015.12.009"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2017.04.010"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13403"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2019.07.006"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15155"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1112562"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.2.187"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.9.1.95"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02279"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3988"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.03.028"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14688","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.14688","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T13:50:52Z","timestamp":1692280252000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,21]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/exd.14688"],"URL":"https:\/\/doi.org\/10.1111\/exd.14688","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,21]]},"assertion":[{"value":"2020-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}