{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:38:07Z","timestamp":1788514687029,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mycosis fungoides (MF) is characterised by malignant CD4<jats:sup>+<\/jats:sup> T\u2010cell infiltrates in the skin. The functional characteristics of the malignant T cells and their interaction with the tumor immune microenvironment is largely unknown. We performed tape stripping of the stratum corneum (SC), a non\u2010invasive technique, to gain insight into the cytokine secretion patterns in MF skin lesions. In addition, we assessed whether the SC cytokine profile of MF lesions is distinct from that of atopic dermatitis (AD) lesions. We compared nine cytokine levels in 20 patients with MF, 10 patients with AD and 10 healthy controls. In patients with MF and AD, lesional SC levels of IL\u20108 and MMP9 were significantly higher than in non\u2010lesional SC and in healthy controls. VEGF\u03b1 was significantly higher in lesional MF and AD skin than in healthy controls. The SC levels of IL\u20101\u03b1 were significantly lower in MF and AD lesions than in healthy controls. There was no specific cytokine profile or inflammation pattern that could reliably distinguish MF from AD. In conclusion, in lesional SC of MF patients, pro\u2010inflammatory cytokines can be detected. As a diagnostic method, tape stripping of lesional SC cannot discriminate MF skin from AD skin.<\/jats:p>","DOI":"10.1111\/exd.14694","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T18:58:37Z","timestamp":1666897117000},"page":"214-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Stratum corneum cytokine levels in mycosis fungoides"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1050-0634","authenticated-orcid":false,"given":"Anh Ly","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Dermatology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Kezic","sequence":"additional","affiliation":[{"name":"Department of Public and Occupational Health Amsterdam Public Health Research Institute, Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Vermeer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Quint","sequence":"additional","affiliation":[{"name":"Department of Dermatology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick","family":"Slieker","sequence":"additional","affiliation":[{"name":"Department of Cell and Chemical Biology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remco","family":"van Doorn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Leiden University Medical Center  Leiden The 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