{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T20:17:22Z","timestamp":1785442642458,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073471"],"award-info":[{"award-number":["82073471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673087"],"award-info":[{"award-number":["81673087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mutations in the \u03b3\u2010secretase complex have been well\u2010described in familial hidradenitis suppurativa (HS). No gene mutations have been identified in sporadic HS, which comprises 60%\u201370% of all HS cases. Obesity and smoking are risk factors for HS and are closely related to DNA methylation, an essential epigenetic phenomenon. Hence, we hypothesized that epigenetic modifications might be involved in sporadic HS. To investigate genes with aberrant methylation in sporadic HS cases and assess their expression in skin lesions and blood from patients with HS. Skin lesion samples and corresponding normal skin were obtained from three patients with HS and subjected to whole\u2010genome DNA methylation sequencing. Blood samples were collected from 20 patients with HS and 20 healthy controls (HCs). The HS mouse model was established by applying tamoxifen to <jats:italic>Ncstn<\/jats:italic><jats:sup>\u0394KC<\/jats:sup> mice. Target gene expression was analysed by immunohistochemistry, immunofluorescence, western blotting, enzyme\u2010linked immunosorbent assay (ELISA) and semiquantitative real\u2010time polymerase chain reaction (RT\u2010qPCR). Among 10\u00a0807 differentially methylated genes, we filtered 2101 genes with hypermethylated promoter regions, and following bioinformatics analyses, we focused on CXC chemokine ligand 16 (<jats:italic>CXCL16<\/jats:italic>). Subsequent functional experiments confirmed the downregulation of CXCL16 and its receptor, CXC chemokine receptor (CXCR) 6, in skin tissue from HS patients and <jats:italic>Ncstn<\/jats:italic><jats:sup>\u0394KC<\/jats:sup> mice. Serum CXCL16 concentrations were also significantly decreased in patients with HS. Our data revealed the downregulation of CXCL16 and CXCR6 in HS.<\/jats:p>","DOI":"10.1111\/exd.14710","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T14:09:30Z","timestamp":1668694170000},"page":"359-367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reduced expression of CXCL16\/CXCR6 is involved in the pathogenesis of hidradenitis suppurativa"],"prefix":"10.1111","volume":"32","author":[{"given":"Zhongshuai","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangqun","family":"Li","sequence":"additional","affiliation":[{"name":"The 2nd Department of Plastic Surgery Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoxi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16677"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JD9.0000000000000204"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2013-131994"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1196284"},{"issue":"1","key":"e_1_2_10_6_1","first-page":"1","article-title":"\u03b3\u2010secretase genetics of hidradenitis suppurativa: a systematic literature review","volume":"5","author":"Wang Z","year":"2020","journal-title":"Dermatology"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.11.911"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.05.009"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.03.009"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.10.051"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.07.020"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.8.5145"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073490"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.04.100"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxm083"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700751"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000761200"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1204733"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.4.1647"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000491819"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2014.947476"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.371"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.1.2.7750"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.10.013"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2665-z"},{"issue":"3","key":"e_1_2_10_26_1","first-page":"84","article-title":"The expression of transmembrane and soluble CXCL16 and the relation with interferon\u2010alpha secretion in patients with Beh\u00e7et's disease","volume":"31","author":"Yilmaz S","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15189-9"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090108"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3242"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew017"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.372"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07155.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07556.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10123410"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.07.015"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.916701"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.007"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903907"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14710","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.14710","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T08:10:53Z","timestamp":1692691853000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/exd.14710"],"URL":"https:\/\/doi.org\/10.1111\/exd.14710","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"2022-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}