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Here, we demonstrate that NETs can activate the absent\u2010in\u2010melanoma\u20102 (AIM2) inflammasome in keratinocytes through the p38\u2010MAPK signalling pathway, and targeting NETs with CI\u2010amidine in vivo reduces AIM2 expression and ameliorates imiquimod\u2010induced psoriasis\u2010like phenotype in mice. Notably, NETs\u2010activated AIM2 in keratinocytes not only promotes IL\u20101\u03b2 production through the classical inflammasome pathway but also promotes IFN\u2010\u03b3 production via X\u2010linked inhibitor of apoptosis protein (XIAP), thereby mediating the immune responses of keratinocytes. In conclusion, our study demonstrates that the NETs\u2010AIM2 axis exerts multiple pro\u2010inflammatory effects on keratinocytes and may serve as a potential target for psoriasis therapy.<\/jats:p>","DOI":"10.1111\/exd.14711","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T16:21:47Z","timestamp":1668874907000},"page":"368-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Neutrophil extracellular traps promote keratinocyte inflammation via <scp>AIM2<\/scp> inflammasome and <scp>AIM2\u2010XIAP<\/scp> in psoriasis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9999-5906","authenticated-orcid":false,"given":"Tianyu","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Dermatology, Xijing Hospital Fourth Military Medical University  Xi'an China"},{"name":"Department of Dermatology, Tangdu Hospital Fourth Military 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