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A direct melanocytic response to melatonin is still uncertain in mammals and human skin pigmentation. Melatonin acts as a free radical scavenger and thus inhibits the initiation of cancer cell growth. Treatment of melanoma sees perspective features in the administration of melatonin along with known chemotherapeutic molecules to improve the efficacy of conventional cytotoxic agents. Being richly supplied with a variety of receptors, melanocytes and melanoma cells can be used as in vitro test models for pharmacological applications of known and novel drugs.<\/jats:p>","DOI":"10.1111\/exd.14715","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T07:09:30Z","timestamp":1669619370000},"page":"324-330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["An exclusive review of melatonin effects on mammalian melanocytes and melanoma"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9589-788X","authenticated-orcid":false,"given":"Muhammad","family":"Mubashshir","sequence":"first","affiliation":[{"name":"School of Allied Sciences Dev Bhoomi Uttarakhand University  Dehradun Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabeel","family":"Ahmad","sequence":"additional","affiliation":[{"name":"School 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