{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:47:58Z","timestamp":1787161678259,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073451"],"award-info":[{"award-number":["82073451"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hydroquinone (HQ) is one of the most effective drugs to treat hyperpigmentary disorders, but often causes skin irritation in clinic. Mast cell plays an important role in contact dermatitis and triggering pseudo\u2010allergic reactions via MRGPRX2. Whether HQ\u2010induced skin irritant reaction through activating mast cells via MRGPRX2 remains unknown. To investigate the role of mast cells in HQ\u2010induced skin irritant reaction and verify whether MRGPRX2 participated in the HQ effect on mast cells which contributed to the pathogenesis of skin irritant reaction, a mouse model of HQ\u2010induced skin irritation was established to observe the local and systemic inflammation associated with mast cell receptor MrgprB2. Human mast cell LAD2 was used to verify the effect of HQ on mast cells via MRGPRX2 by knocking down with siRNA. As a result, mast cells were involved in the development of HQ\u2010induced irritant reaction, and local inflammation is closely related to mast cell receptor MrgprB2. HQ could activate mast cells via MRGPRX2, causing changes in calcium concentration, degranulation and release of inflammatory cytokines which lead to skin irritant reaction. In conclusion, HQ\u2010induced skin irritant reaction could be skin pseudo\u2010allergic reactions achieved by activating mast cells via MRGPRX2.<\/jats:p>","DOI":"10.1111\/exd.14723","type":"journal-article","created":{"date-parts":[[2022,12,4]],"date-time":"2022-12-04T07:04:38Z","timestamp":1670137478000},"page":"436-446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hydroquinone\u2010induced skin irritant reaction could be achieved by activating mast cells via mas\u2010related G protein\u2013coupled receptor\n                    <scp>X2<\/scp>"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4877-4289","authenticated-orcid":false,"given":"Yi","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Dermatology, Northwest Hospital The Second Hospital Affiliated to Xi'an Jiaotong University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueshan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwest Hospital The Second Hospital Affiliated to Xi'an Jiaotong University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Shaanxi Provincial Hospital of Chinese Medicine  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwest Hospital The Second Hospital Affiliated to Xi'an Jiaotong University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwest Hospital The Second Hospital Affiliated to Xi'an Jiaotong University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwest Hospital The Second Hospital Affiliated to Xi'an Jiaotong University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwest Hospital The Second Hospital Affiliated to Xi'an Jiaotong University  China"},{"name":"Department of Dermatology The Second Affiliated Hospital of Baotou Medical College, University of Science and Technology  Baotou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwest Hospital The Second Hospital Affiliated to Xi'an Jiaotong University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delu","family":"Che","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwest Hospital The Second Hospital Affiliated to Xi'an Jiaotong University  China"},{"name":"Center for Dermatology Disease, Precision Medical Institute Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8731-6267","authenticated-orcid":false,"given":"Songmei","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwest Hospital The Second Hospital Affiliated to Xi'an Jiaotong University  China"},{"name":"Center for Dermatology Disease, Precision Medical Institute Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2007.08.085"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/542168"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01670.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00488-w"},{"issue":"6","key":"e_1_2_10_6_1","first-page":"665","article-title":"Safety of skin care products during pregnancy","volume":"57","author":"Bozzo P","year":"2011","journal-title":"Can Fam Physician"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02246.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2003.02017.x"},{"issue":"1","key":"e_1_2_10_9_1","first-page":"67","article-title":"Efficacy and safety of a new triple\u2010combination agent for the treatment of facial melasma","volume":"72","author":"Taylor SC","year":"2003","journal-title":"Cutis"},{"issue":"6","key":"e_1_2_10_10_1","first-page":"362","article-title":"A microsponge formulation of hydroquinone 4% and retinol 0.15% in the treatment of melasma and postinflammatory hyperpigmentation","volume":"74","author":"Grimes PE","year":"2004","journal-title":"Cutis"},{"issue":"1","key":"e_1_2_10_11_1","first-page":"57","article-title":"Hydroquinone 4%, tretinoin 0.05%, fluocinolone acetonide 0.01%: a safe and efficacious 12\u2010month treatment for melasma","volume":"75","author":"Torok HM","year":"2005","journal-title":"Cutis"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.02.009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2002.01451.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i3299"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.02.009"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/reveh-2014-0060"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.08.027"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.013"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2017.06.002"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.03.049"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13292"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2019.07.007"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106258"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04126-6"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12634"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.03.028"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200109000-00019"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201002300307"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14723","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.14723","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T04:10:30Z","timestamp":1692677430000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,19]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/exd.14723"],"URL":"https:\/\/doi.org\/10.1111\/exd.14723","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,19]]},"assertion":[{"value":"2022-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}