{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:30:34Z","timestamp":1788949834501,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000545","name":"British Association of Dermatologists","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oral lichen planus (OLP) confers an approximately 1% risk of transformation to oral squamous cell carcinoma (OSCC). Early identification of high\u2010risk OLP would be very helpful for optimal patient management. We aimed to discover specific tissue\u2010based protein biomarkers in patients with OLP who developed OSCC compared to those who did not. We used laser capture microdissection\u2013 and nanoLC\u2013tandem mass spectrometry to assess protein expression in fixed lesional mucosal specimens in patients with indolent OLP (no OSCC after at least 5\u2010year follow\u2010up, <jats:italic>n<\/jats:italic>\u00a0=\u20096), transforming OLP (non\u2010dysplastic epithelium with lichenoid inflammation marginal to OSCC, <jats:italic>n<\/jats:italic>\u00a0=\u20096) or normal oral mucosa (NOM, <jats:italic>n<\/jats:italic>\u00a0=\u20095). Transforming OLP protein profile was enriched for actin cytoskeleton, mitochondrial dysfunction and oxidative phosphorylation pathways. CA1, TNNT3, SYNM and MB were overexpressed, and FBLN1 was underexpressed in transforming OLP compared with indolent OLP. Integrin signalling and antigen presentation pathways were enriched in both indolent and transforming OLP compared with NOM. This proteomic study provides potential biomarkers, such as CA1 overexpression, for higher\u2010risk OLP. While further validation studies are needed, we propose that epithelial\u2013mesenchymal transition may be involved in OLP carcinogenesis.<\/jats:p>","DOI":"10.1111\/exd.14738","type":"journal-article","created":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T10:08:16Z","timestamp":1672567696000},"page":"502-510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Differential proteomic expression in indolent versus transforming oral lichen planus"],"prefix":"10.1111","volume":"32","author":[{"given":"Fangyi","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey A.","family":"Gleue","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Deschaine","sequence":"additional","affiliation":[{"name":"Department of Dermatology Florida State University  Pensacola Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surendra","family":"Dasari","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8965-5403","authenticated-orcid":false,"given":"Julio C.","family":"Sartori\u2010Valinotti","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13704"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13323"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13741"},{"key":"e_1_2_12_5_1","first-page":"25","article-title":"Oral lichen planus has a very low malignant transformation rate: a systematic review and meta\u2010analysis using strict diagnostic and inclusion criteria","volume":"25","author":"Idrees M","year":"2020","journal-title":"J Oral Pathol 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