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The discovery of recessive <jats:italic>IL36RN<\/jats:italic> mutations associated with GPP has transformed our understanding of disease drivers, paving the way for the development of targeted anti\u2010IL36 therapeutics. In the light of these remarkable successes, this viewpoint reviews the significance of <jats:italic>IL36RN<\/jats:italic> mutations in GPP, their functional impact and their correlation with clinical phenotypes. It then covers the discovery of further genetic determinants (recessive <jats:italic>MPO<\/jats:italic> mutations) and risk factors (<jats:italic>AP1S3<\/jats:italic> and <jats:italic>CARD14<\/jats:italic> low\u2010frequency variants) for the disease. It discusses the growing evidence for genetic complexity in GPP and concludes by outlining collaborative strategies that may be adopted to overcome the challenges ahead.<\/jats:p>","DOI":"10.1111\/exd.14746","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T13:39:40Z","timestamp":1673876380000},"page":"1188-1193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A viewpoint on the genetic determinants of generalised pustular psoriasis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2432-5793","authenticated-orcid":false,"given":"Francesca","family":"Capon","sequence":"first","affiliation":[{"name":"Department of Medical and Molecular Genetics, School of Basic and Medical Biosciences King's College London  London 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