{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:51Z","timestamp":1787014191715,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T00:00:00Z","timestamp":1677369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pustular psoriasis (PP) is an uncommon subtype of psoriasis with distinct genetic features and clinical phenotypes. Patients with PP tend to experience frequent flares and significant morbidity. This study aims to determine the clinical characteristics, co\u2010morbidities and treatment of PP patients in Malaysia. This was a cross\u2010sectional study of patients with PP notified to the Malaysian Psoriasis Registry (MPR) between January 2007 and December 2018. Of 21\u2009735 psoriasis patients, 148 (0.7%) had pustular psoriasis. Of these, 93 (62.8%) were diagnosed with generalized pustular psoriasis (GPP) and 55 (37.2%) with localized PP (LPP). The mean age for pustular psoriasis onset was 31.71\u2009\u00b1\u200918.33\u2009years with a male to female ratio of 1:2.1. Patients with PP were more likely to have dyslipidaemia (23.6% vs. 16.5%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.022), severe disease (Body surface area &gt;10 and\/or Dermatology Life Quality Index [DLQI] &gt;10) (64.8% vs. 50%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.003) and require systemic therapy (51.4% vs. 13.9%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) compared to non\u2010PP patients. Patients with PP also suffered greater impairment to their quality of life (DLQI &gt;10, 48.9% vs. 40.3%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.046), had more days off school\/work (2.06\u2009\u00b1\u20096.09 vs. 0.5\u2009\u00b1\u20094.91,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.004) and a higher mean number of hospitalizations (0.31\u2009\u00b1\u20090.95 vs. 0.05\u2009\u00b1\u20091.22,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.001) in 6\u00a0months compared to non\u2010PP patients. Overall, 0.7% of psoriasis patients in the MPR had pustular psoriasis. Patients with PP had a higher rate of dyslipidaemia, severe disease, greater impairment of quality of life and systemic therapy usage compared to other psoriasis subtypes.\n                  <\/jats:p>","DOI":"10.1111\/exd.14770","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T07:58:20Z","timestamp":1676534300000},"page":"1253-1262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pustular psoriasis in Malaysia: A review of the Malaysian Psoriasis Registry 2007\u20132018"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0501-3527","authenticated-orcid":false,"given":"Xin Yun","family":"Teoh","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Queen Elizabeth, Ministry of Health Malaysia  Kota Kinabalu Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9987-7547","authenticated-orcid":false,"given":"Robinson","family":"Suganthy","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Kuala Lumpur, Ministry of Health Malaysia  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sook Yee Michelle","family":"Voo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Queen Elizabeth, Ministry of Health Malaysia  Kota Kinabalu Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Moon","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Kuala Lumpur, Ministry of Health Malaysia  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Malaysian Psoriasis Registry Working 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okays spesolimab first treatment for generalized pustular psoriasis. Medscape. Accessed September 3 2022.https:\/\/www.medscape.com\/viewarticle\/980188. 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