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Certain nutraceuticals \u2013 most prominently spirulina, soy isoflavones, long\u2010chain omega\u20103 fatty acids, the green tea catechin epigallocatechin gallate (EGCG) and Polypodium leucotomos extract \u2013 have been shown to oppose photocarcinogenesis, as well as sunburn and photoaging, in UVB\u2010exposed hairless mice. It is proposed that spirulina provides protection in this regard via phycocyanobilin\u2010mediated inhibition of Nox1\u2010dependent NADPH oxidase; that soy isoflavones do so by opposing NF\u2010\u03baB transcriptional activity via oestrogen receptor\u2010beta; that the benefit of eicosapentaenoic acid reflects decreased production of prostaglandin E2; and that EGCG counters UVB\u2010mediated phototoxicity via inhibition of the epidermal growth factor receptor. The prospects for practical nutraceutical down\u2010regulation of photocarcinogenesis, sunburn, and photoaging appear favourable.<\/jats:p>","DOI":"10.1111\/exd.14777","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T13:44:00Z","timestamp":1677073440000},"page":"722-730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Nutraceutical strategies for alleviation of <scp>UVB<\/scp> phototoxicity"],"prefix":"10.1111","volume":"32","author":[{"given":"Mark F.","family":"McCarty","sequence":"first","affiliation":[{"name":"Catalytic Longevity Foundation  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Benzvi","sequence":"additional","affiliation":[{"name":"Chaim Sheba Medical Center The Zabludowicz Research Center for Autoimmune Diseases  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristo","family":"Vojdani","sequence":"additional","affiliation":[{"name":"Immunosciences Lab., Inc.  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