{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:31:41Z","timestamp":1791901901525,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T00:00:00Z","timestamp":1679097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of topical non\u2010antibiotic acne treatment on skin microbiota have rarely been demonstrated. In the study, we randomized 45 mild acne vulgaris participants into three treatment groups, including a cream\u2010gel dermocosmetic containing Aqua Posae Filiformis, lipohydroxy acid, salicylic acid, linoleic acid, niacinamide and piroctone olamine (DC), retinoic acid 0.025% cream (VAA) and benzoyl peroxide 2.5% gel (BP). At months 0, 1 and 3, skin specimens were swabbed from the cheek and forehead and sequenced by targeting V3\u2010V4 regions of the 16\u2009S rRNA gene. QIIME2 was used to characterize bacterial communities. Acne severity, sebum level and tolerability were assessed concomitantly in each visit. We found that both VAA and BP could significantly reduce the bacterial diversity at month 1 (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a00.010 and 0.004 respectively), while no significant reduction was observed in DC group. The microbiota compositions also significantly altered for beta diversity in all treatments (all <jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a00.001). An increased <jats:italic>Cutibacterium<\/jats:italic> with decreased <jats:italic>Staphylococcus<\/jats:italic> relative abundance was observed at months 1 and 3 in DC group, while an opposite trend was demonstrated in VAA and BP groups. These findings suggest a potential impact of DC, VAA and BP on the diversity and composition profiles of the skin microbiota in mild acne participants.<\/jats:p>","DOI":"10.1111\/exd.14779","type":"journal-article","created":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T10:24:17Z","timestamp":1677407057000},"page":"906-914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Distinct skin microbiome modulation following different topical acne treatments in mild acne vulgaris patients: A randomized, investigator\u2010blinded exploratory study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4017-5473","authenticated-orcid":false,"given":"Chanidapa","family":"Wongtada","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Dermatology, Faculty of Medicine Chulalongkorn University  Bangkok 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