{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:36:37Z","timestamp":1777505797716,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Generalized pustular psoriasis (GPP) is a clinical entity distinct from psoriasis, associated with a poor clinical prognosis, often resulting in severe systemic complications and mortality. The relapsing nature of the disease with recurrent or intermittent flares imposes a significant burden on patients' quality of life (QoL). Although inadequately studied, QoL data in GPP patients has been a recent point of investigation. We conducted a literature search on PubMed\/MEDLINE using the following search terms: \u2018generalized pustular psoriasis\u2019 OR \u2018pustular psoriasis\u2019 AND \u2018quality of life\u2019. We identified 12 relevant articles that provide insight into the large impact of GPP on the QoL of patients, the burden of the disease and the treatment, and the success of new treatment options in making a clinically important difference to QoL. This review illustrates a need for routine assessment of the QoL in interventional clinical trials for GPP and during physician encounters. This information can help guide clinicians on how to tailor the treatment approach from the patient's perspective or illustrate whether new therapies offer meaningful benefits to patient care as we enter an era of exciting new treatments for this challenging condition.<\/jats:p>","DOI":"10.1111\/exd.14787","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T03:18:36Z","timestamp":1678936716000},"page":"1227-1234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A narrative review of studies assessing the quality of life in patients with generalized pustular psoriasis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1612-3887","authenticated-orcid":false,"given":"Payal M.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital Harvard University  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie N.","family":"Sanchez\u2010Melendez","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"},{"name":"Ponce Health Sciences University, School of Medicine  Ponce Puerto Rico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod E.","family":"Nambudiri","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts 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