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In erosive oral LP, we found HPV16\u2010specific activated CTL in lesions, supporting a pathogenic contribution of HPV16. Here, we investigated whether a similar scenario occurs in other clinical forms of LP and in lichen sclerosus et atrophicus (LSA), another chronic disease also affecting the mucosa and\/or the skin. Blood CTL from LP and LSA patients expressed significant higher levels of granzyme B, perforin and CD107a proteins than healthy donors. Expansions of TCRV\u00df3<jats:sup>+<\/jats:sup>CTL, with presence of TCR clonotypes identical to those previously detected in erosive oral LP, were found both in blood and mucosal\/skin lesions of LP, and not of LSA patients. These expansions were enriched with HPV16\u2010specific CD8<jats:sup>+<\/jats:sup>T\u2010cells as shown by their recognition of the E7<jats:sub>11\u201020<\/jats:sub>immunodominant epitope. In LSA patients, the peripheral repertoire of CTL was oligoclonal for TCRV\u00df6<jats:sup>+<\/jats:sup>CTL. Finally, although patients with LP and LSA have developed antibodies against HPV16 capsid L1, antibodies against HPV16 E6 were only observed in patients with LP. Overall, our data collectively suggest an involvement of HPV16\u2010specific CTL in different clinical forms of LP, not only in erosive oral LP, while a different scenario operates in LSA.<\/jats:p>","DOI":"10.1111\/exd.14788","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T04:34:50Z","timestamp":1678941290000},"page":"859-868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Human papilloma virus\u201016\u2010specific<scp>CD8<\/scp>+ T\u2010cell expansions characterize different clinical forms of lichen planus and not lichen sclerosus et atrophicus"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9049-8700","authenticated-orcid":false,"given":"Manuelle","family":"Viguier","sequence":"first","affiliation":[{"name":"Department of dermatology, H\u00f4pital Robert\u2010Debr\u00e9 University of Reims Champagne\u2010Ardenne (URCA), EA7509 IRMAIC 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