{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:02:28Z","timestamp":1792544548026,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T00:00:00Z","timestamp":1679097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hidradenitis suppurativa is a complex inflammatory disease in which predicting therapeutic response remains challenging. IL\u201023 interacts with sex hormones but the relationships between the two in HS remains uninvestigated. To assess whether baseline clinical, hormonal or molecular markers are associated with clinical response to IL\u201023 antagonism with risankizumab in hidradenitis suppurativa. Twenty six individuals with Hurley stage 2\/3 disease were administered risankizumab 150\u2009mg\u2009Week 0, 4, 12. Baseline sex hormones and skin biopsies were taken. Clinical response at Week 16 assessed by the HiSCR, and differences between responders and non\u2010responders assessed. Eighteen of 26 participants achieved HiSCR50 at week 16 (69.2%). Clinical response to IL\u201023 antagonism was associated with male gender, elevated total serum testosterone and decreased levels of FSH. Stratification by clinical responders\/nonresponders identified differentially expressed genes including\n                    <jats:italic>PLPP4<\/jats:italic>\n                    and\n                    <jats:italic>MAPK10<\/jats:italic>\n                    . Immunohistochemistry identified elevated numbers of CD11c, IL\u201017A and IL\u201017F positive cells compared to nonresponders. CD11c\u2009+\u2009cells significantly correlated with serum levels of total testosterone and inversely correlated with serum FSH. Clinical response to IL\u201023 antagonism in HS is associated with serum sex hormones, Th17 polarized inflammation in lesional tissue and CD11c\u2009+\u2009cells. These potential therapeutic biomarkers require further validation in larger cohorts but may suggest potential targeted HS therapy.\n                  <\/jats:p>","DOI":"10.1111\/exd.14789","type":"journal-article","created":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T21:44:13Z","timestamp":1679175853000},"page":"869-877","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Baseline clinical, hormonal and molecular markers associated with clinical response to\n                    <scp>IL<\/scp>\n                    \u201023 antagonism in hidradenitis suppurativa: A prospective cohort study"],"prefix":"10.1111","volume":"32","author":[{"given":"A.","family":"Flora","sequence":"first","affiliation":[{"name":"Department of Dermatology Liverpool Hospital  Sydney New South Wales Australia"},{"name":"Laboratory of Translational Cutaneous Medicine Ingham Institute  Sydney New South Wales Australia"},{"name":"University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. K.","family":"Kozera","sequence":"additional","affiliation":[{"name":"Department of Dermatology Liverpool Hospital  Sydney New South Wales Australia"},{"name":"Laboratory of Translational Cutaneous Medicine Ingham Institute  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Jepsen","sequence":"additional","affiliation":[{"name":"Holdsworth House Medical Practice  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Gill","sequence":"additional","affiliation":[{"name":"University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Xu","sequence":"additional","affiliation":[{"name":"University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W.","family":"Frew","sequence":"additional","affiliation":[{"name":"Department of Dermatology Liverpool Hospital  Sydney New South Wales Australia"},{"name":"Laboratory of Translational Cutaneous Medicine Ingham Institute  Sydney New South Wales Australia"},{"name":"University of New South Wales  Sydney New South Wales Australia"},{"name":"Holdsworth House Medical Practice  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.06.019"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504370"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.07.010"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18556"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.11.018"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1654067"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14338"},{"key":"e_1_2_11_9_1","unstructured":"Clinicaltrials.gov (NCT 03628924).A study to evaluate the efficacy safety and tolerability of guselkumab for the treatment of participants with moderate to severe hidradenitis suppurativa (HS) (NOVA).https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03628924. 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