{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T02:42:44Z","timestamp":1777171364706,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bullous pemphigoid (BP) is an autoimmune bullous disease, characterized by autoantibodies targeting BP180 and BP230. The role of interleukin (IL)\u201036, a potent chemoattractant for granulocytes, in BP remains elusive.The expression of IL\u201036 cytokines (IL\u201036\u03b1, \u03b2, \u03b3) and their antagonists (IL\u201036Ra and IL\u201038) was analysed in the skin and serum samples of patients with BP (<jats:italic>n<\/jats:italic>\u00a0=\u200931), psoriasis (<jats:italic>n<\/jats:italic>\u00a0=\u200910) and healthy controls (HC) (<jats:italic>n<\/jats:italic>\u00a0=\u200914) by quantitative polymerase chain reaction and enzyme linked immunosorbent assay, respectively. Skin and serum levels of all cytokines were correlated with the Bullous Pemphigoid Disease Area Index (BPDAI) score and with the serum concentration of pathogenic antibodies.IL\u201036\u03b1, IL\u201036\u03b2, IL\u201036\u03b3 and IL\u201036Ra were significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.05) overexpressed in BP skin compared to HC, without remarkable differences relative to psoriasis skin. The expression of IL\u201038 was significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.05) higher in BP compared to psoriasis skin.IL\u201036\u03b1 and \u03b3, but not \u03b2, serum concentrations were significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.05) higher in BP compared to HC. IL\u201036\u03b3 was significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.05) more expressed in the serum of psoriasis patients than BP. The serum concentration of IL\u201036Ra and IL\u201038 were similar between BP and HC, while IL\u201038 serum levels were significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.05) higher in BP compared to psoriasis patients. Serum IL\u201036\u03b1 correlated significantly with BPDAI (<jats:italic>r<\/jats:italic>\u00a0=\u20090.5 <jats:italic>p<\/jats:italic>\u00a0=\u20090.001).IL\u201036 agonists are increased in BP patients, both locally and systemically. Serum IL\u201036\u03b1 might represent a potential biomarker for BP. An inefficient balance between IL\u201036 agonists and antagonists is likely to occur during BP inflammation.<\/jats:p>","DOI":"10.1111\/exd.14791","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:29:35Z","timestamp":1679358575000},"page":"915-921","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Interleukin\u201036 cytokines are overexpressed in the skin and sera of patients with bullous pemphigoid"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5106-4042","authenticated-orcid":false,"given":"Roberto","family":"Maglie","sequence":"first","affiliation":[{"name":"Section of Dermatology, Department of Health Sciences University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Mercurio","sequence":"additional","affiliation":[{"name":"Experimental Immunology Laboratory Istituto Dermopatico dell'Immacolata (IDI\u2010IRCCS)  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Morelli","sequence":"additional","affiliation":[{"name":"Experimental Immunology Laboratory Istituto Dermopatico dell'Immacolata (IDI\u2010IRCCS)  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Madonna","sequence":"additional","affiliation":[{"name":"Experimental Immunology Laboratory Istituto Dermopatico dell'Immacolata (IDI\u2010IRCCS)  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adele","family":"Salemme","sequence":"additional","affiliation":[{"name":"Molecular and Cell Biology laboratory Istituto Dermopatico dell'Immacolata (IDI\u2010IRCCS)  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria E.","family":"Baffa","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Health Sciences University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lavinia","family":"Quintarelli","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Health Sciences University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni M.","family":"Di\u00a0Zenzo","sequence":"additional","affiliation":[{"name":"Molecular and Cell Biology laboratory Istituto Dermopatico dell'Immacolata (IDI\u2010IRCCS)  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiliano","family":"Antiga","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Health Sciences University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Albanesi","sequence":"additional","affiliation":[{"name":"Experimental Immunology Laboratory Istituto Dermopatico dell'Immacolata (IDI\u2010IRCCS)  Rome 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