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CHD4 is upregulated in DM skin biopsies and could potentially affect DM pathophysiology as it binds endogenous DNA with a high affinity (KD\u2009=\u20090.2\u2009nM\u2009\u00b1\u20090.076\u2009nM) and forms CHD4\u2010DNA complexes. The complexes are localized in the cytoplasm of UV\u2010radiated and transfected HaCaTs and amplify the expression of interferon (IFN) regulated genes and the amount of functional CXCL10 protein stronger than DNA alone. The enhancement of the type I IFN pathway activation in HaCaTs through CHD4\u2010DNA signalling suggests a possible mechanism for the sustainment of the pro\u2010inflammatory vicious cycle in DM skin lesions.<\/jats:p>","DOI":"10.1111\/exd.14799","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T16:10:30Z","timestamp":1680192630000},"page":"965-974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dermatomyositis autoantigen <scp>CHD4<\/scp> forms immune stimulatory complexes with endogenous <scp>DNA<\/scp>"],"prefix":"10.1111","volume":"32","author":[{"given":"Tugce","family":"Guel","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Scholtissek","sequence":"additional","affiliation":[{"name":"Department of Dermatology and 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