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Pyroptosis is known as a regulated inflammatory cell death. While its association with immune response to various inflammatory disorders is well established, little is known about its functional relevance of rosacea. So, we aimed to explore and enrich the pathogenesis involved in pyroptosis\u2010related rosacea aggravations. In this study, we evaluated the pyroptosis\u2010related patterns of rosacea by consensus clustering analysis of 45 ferroptosis\u2010related genes (FRGs), with multiple immune cell infiltration analysis to identify the pyroptosis\u2010mediated immune response in rosacea using GSE65914 dataset. The co\u2013co\u2010work between PRGs and WGCNA\u2010revealed hub genes has established using PPI network. FRG signature was highlighted in rosacea using multi\u2010transcriptomic and experiment analysis. Based on this, three distinct pyroptosis\u2010related rosacea patterns (non\/moderate\/high) were identified, and the notably enriched pathways have revealed through GO, KEGG and GSEA analysis, especially immune\u2010related pathways. Also, the XCell\/MCPcount\/ssGSEA\/Cibersort underlined the immune\u2010related signalling (NK cells, Monocyte, Neutrophil, Th2 cells, Macrophage), whose hub genes were identified through WGCNA (NOD2, MYD88, STAT1, HSPA4, CXCL8). Finally, we established a pyroptosis\u2010immune co\u2010work during the rosacea aggravations. FRGs may affect the progression of rosacea by regulating the immune cell infiltrations. In all, pyroptosis with its mediated immune cell infiltration is a critical factor during the development of rosacea.<\/jats:p>","DOI":"10.1111\/exd.14812","type":"journal-article","created":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T04:09:52Z","timestamp":1682136592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>Pyroptosis\u2010related<\/scp>\n                    gene signature elicits immune response in rosacea"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0119-6394","authenticated-orcid":false,"given":"Xi\u2010min","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Xiangya Hospital Central South University  Changsha China"},{"name":"Department of Anatomy and Neurobiology, School of Basic Medical Science Central South University  Changsha 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