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The selective and rapid absorption of energy by the blood causes heating of the vascular wall and surrounding structures, like perivascular nerves. Several studies indicate the importance of nerves in psoriatic inflammation. Interestingly, denervation leads to a spontaneous remission of the psoriatic lesion. Among all dermal nerves, the perivascular nerves are the most likely to be affected during PDL treatment, possibly impairing the neuro\u2010inflammatory processes that promote T\u2010cell activation, expression of adhesion molecules, leukocyte infiltration and cytokine production. Repeated PDL therapy could cause a prolonged loss of innervation through nerve damage, or result in a \u2018reset\u2019 of neurogenic inflammation after temporary denervation. The current hypothesis provides strong arguments that PDL treatment affects nerve fibres in the skin and thereby abrogates the persistent and exaggerated inflammatory process underlying psoriasis, causing a long\u2010term remission of psoriasis.<\/jats:p>","DOI":"10.1111\/exd.14816","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T10:32:09Z","timestamp":1682073129000},"page":"1165-1173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of pulsed dye laser treatment in psoriasis: A nerve\u2010wrecking process?"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2217-7742","authenticated-orcid":false,"given":"Meagan","family":"Doppegieter","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering &amp; Physics, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"van der Beek","sequence":"additional","affiliation":[{"name":"ZBC MultiCare, Independent Treatment Center for Dermatology  Hilversum The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik N. 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