{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:54:02Z","timestamp":1792547642551,"version":"4.5.0"},"reference-count":70,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Atopy may be a facilitating factor in some alopecia areata (AA) patients with early disease onset and more severe\/extensive AA. The underlying immune mechanisms are unknown, but allergen responses may support a pro\u2010inflammatory environment that indirectly promotes AA. To investigate the long\u2010term effect of allergen immunotherapy (AIT) against house dust mite (HDM) allergy on disease severity and prognosis for AA patients. An observational comparative effectiveness study was conducted on 69 AA patients with HDM allergy. 34 patients received conventional\/traditional AA treatment (TrAA) plus AIT (AIT\u2010TrAA), and 35 patients received TrAA alone. Serum total immunoglobulin E (tIgE), HDM specific IgE (sIgE), HDM specific IgG4 (sIgG4) and cytokines (IL\u20104, IL\u20105, IL\u201010, IL\u201012, IL\u201013, IL\u201033, IFN\u03b3) were quantified in these patients, together with 58 non\u2010allergic AA patients and 40 healthy controls. At the end of the 3\u2010year desensitization course, the AIT\u2010TrAA group presented with lower SALT scores than the TrAA group, especially in non\u2010alopecia totalis\/universalis (AT\/U) patients and pre\u2010adolescent AT\/U patients (age\u2009\u2264\u200914). In patients with elevated tIgE levels before AIT, a decrease in tIgE was correlated to reduced extent of AA on completion of the AIT course. After desensitization, elevation of IL\u20105 and decrease of IL\u201033 were observed in HDM allergic\u2010AA patients. Desensitization to HDM in allergic AA patients reduces the severity of relapse\u2010related hair loss over the 3\u2010year AIT treatment course, possibly via opposing Th2 dominance. This adjunctive treatment may help reduce disease severity and curtail the disease process in allergic patients with AA.<\/jats:p>","DOI":"10.1111\/exd.14819","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T07:10:00Z","timestamp":1682665800000},"page":"1108-1119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Allergen desensitization reduces the severity of relapsed alopecia areata in dust\u2010mite allergic patients"],"prefix":"10.1111","volume":"32","author":[{"given":"Zixun","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou P.R. China"},{"name":"Department of Dermatology First Affiliated Hospital of Kunming Medical University  Kunming P.R. 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