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Therefore, we aimed to determine KC\u2010derived cytokine expression in distinct healthy skin regions (gland\u2010poor [GP], sebaceous gland\u2010rich [SGR] and apocrine gland\u2010rich [AGR]), and their changes in skin diseases of the given regions (atopic dermatitis [AD], papulopustular rosacea [PPR] and psoriasis). Cytokines were analysed at the mRNA and protein levels, and literature analysis was performed for functional categorization. The three regions showed characteristically different cytokine patterns. GP was featured by an IL\u201025\/IL\u201033\/IL\u201036RA\/IL\u201038\/IL\u201018 cytokine milieu, SGR was characterized by IL\u201023\/IL\u201017C\/IL\u201018, and AGR skin exhibited a mixed IL\u201025\/IL\u201033\/IL\u201023\/IL\u201018 profile. Literature analyses revealed different homeostatic and proinflammatory roles of these cytokine patterns (Th2 related in GP, Th17 related in SGR and mixed Th2\/Th17 in AGR). In skin diseases which are primarily epidermal cytokine\u2010driven (AD, PPR), the level of the regionally characteristic cytokines were further elevated, in contrast to the autoantigen\u2010driven psoriasis, where the cytokine pattern was independent from the localization. Healthy skin regions are equipped with different KC\u2010derived cytokine profiles, which may influence each region's capability of mediator production in certain types of dermatoses.<\/jats:p>","DOI":"10.1111\/exd.14820","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T04:55:09Z","timestamp":1682312109000},"page":"1120-1131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cytokine profile of the epidermis is region specific and may determine the characteristics of inflammation"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5051-5630","authenticated-orcid":false,"given":"Lilla","family":"Szab\u00f3","sequence":"first","affiliation":[{"name":"Department of Dermatology, Centre of Excellence, Faculty of Medicine University of Debrecen  Debrecen Hungary"},{"name":"Doctoral School of Clinical Immunology and Allergology University of Debrecen  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