{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:24:01Z","timestamp":1791645841702,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hematoporphyrin monomethyl ether\u2010photodynamic therapy (HMME\u2010PDT) has achieved encouraging clinical outcomes in adult port\u2010wine stain (PWS). Optimal treatment option for children with PWS was minimal. To compare whether the clinical effectiveness of HMME\u2010PDT with the 5\u2010min (fast) administration treatment regimen (FATR) was better than the 20\u2010min (slow) administration treatment regimen (SATR) for PWS of children in vivo and in vitro. Thirty\u2010four children with PWS were divided into two groups including FATR and SATR. The two groups received three times HMME\u2010PDT, respectively. Treatment efficacy and safety were evaluated in vivo and in vitro<jats:italic>.<\/jats:italic> Erythema index (EI) was used to evaluate the clinical outcomes. Both FATR and SATR were effective and safe in children with PWS after HMME\u2010PDT. There were significance differences between the two groups in reductions of EI after the second treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and the third treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) with HMME\u2010PDT. The serum HMME concentration reach the peak level at short time compare with SATR group. A significance increased superoxide levels were observed in FATR group compare to SATR groups in vitro (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Our study suggested that HMME\u2010PDT was effective and safe for children with PWS, the therapy regimen with FATR was better in clinical efficacy than that of the SATR.<\/jats:p>","DOI":"10.1111\/exd.14834","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T05:21:53Z","timestamp":1683609713000},"page":"1371-1382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical efficacy and safety of two different hematoporphyrin monomethyl ether\u2010mediated photodynamic therapy regimen in Chinese children with <scp>port\u2010wine<\/scp> stain"],"prefix":"10.1111","volume":"32","author":[{"given":"Sheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Capital Institute of Pediatrics, Capital Institute of Pediatrics\u2010Peking University Teaching Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Municipal Key Laboratory of Child Development and Nutriomics, Translational Medicine Laboratory Capital Institute of Pediatrics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongguang","family":"Chen","sequence":"additional","affiliation":[{"name":"Peking University Sixth Hospital, Peking University Institute of Mental Health, Key Laboratory of Mental Health, Ministry of Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huina","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Capital Institute of Pediatrics, Capital Institute of Pediatrics\u2010Peking University Teaching Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Capital Institute of Pediatrics, Capital Institute of Pediatrics\u2010Peking University Teaching Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Capital Institute of Pediatrics, Capital Institute of Pediatrics\u2010Peking University Teaching Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Capital Institute of Pediatrics, Capital Institute of Pediatrics\u2010Peking University Teaching Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Capital Institute of Pediatrics, Capital Institute of Pediatrics\u2010Peking University Teaching Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Capital Institute of Pediatrics, Capital Institute of Pediatrics\u2010Peking University Teaching Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Municipal Key Laboratory of Child Development and Nutriomics, Translational Medicine Laboratory Capital Institute of Pediatrics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaolei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Capital Institute of Pediatrics, Capital Institute of Pediatrics\u2010Peking University Teaching Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.11.938"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1213507"},{"issue":"11","key":"e_1_2_12_4_1","first-page":"1145","article-title":"Port\u2010wine stains: a focused review on their management","volume":"16","author":"Updyke KM","year":"2017","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.10.039"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156219"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20788"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20529"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa064329"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2017.4392"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12204"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15599"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-011-0903-4"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2018.06.006"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12130"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2010.00555.x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2014.09.004"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955710791330963"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2007.00160.x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1997.tb08581.x"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2011.132"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2018.09.012"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12384"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2017.09.013"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2011.09.004"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1037\/dev0000727"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jecp.2019.01.004"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1037\/emo0000703"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000881"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2021.102568"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2012.10.001"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2007.00256.x"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02129.x"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2014.06.004"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16094"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20176431"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2019.01.008"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.1323"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12150"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23134"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13166"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200038030-00002"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077727"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2010.05.001"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T06:13:48Z","timestamp":1694153628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,8]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/exd.14834"],"URL":"https:\/\/doi.org\/10.1111\/exd.14834","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,8]]},"assertion":[{"value":"2023-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}