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With the approval of a GPP flare treatment in several countries occurring only recently, the socioeconomic burden associated with GPP is not well established. To highlight current evidence for patient burden, healthcare resource utilization (HCRU) and costs associated with GPP. Patient burden results from serious complications including sepsis and cardiorespiratory failure causing hospitalization and death. HCRU is driven by high hospitalization rates and treatment costs. The mean duration of a GPP hospital stay ranges from 10 to 16\u2009days. A quarter of patients require intensive care, and the mean intensive care stay is 18\u2009days. In comparison to patients with plaque psoriasis (PsO), patients with GPP have: a 64% higher score on the Charlson Comorbidity Index; higher hospitalization rates (\u226436.3% vs. \u226423.3%); lower overall quality of life, and higher symptom scores for pain, itch, fatigue, anxiety and depression; direct costs associated with treatment 1.3\u2010 to 4.5\u2010fold higher; higher rates of disabled work status (20.0% vs. 7.6%); and increased presenteeism (i.e. worse impairment at work), impaired daily activities, and medically related absenteeism. Current medical management and drug treatment utilising non\u2010GPP\u2010specific therapies impose a significant patient and direct economic burden. GPP also imposes an indirect economic burden by increasing work productivity impairment and medically related absenteeism. This high level of socioeconomic burden reinforces the need for new therapies with proven efficacy in the treatment of GPP.<\/jats:p>","DOI":"10.1111\/exd.14841","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T05:41:26Z","timestamp":1686634886000},"page":"1219-1226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A narrative review of the socioeconomic burden associated with generalised pustular psoriasis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5242-4057","authenticated-orcid":false,"given":"Thomas M.","family":"Zimmermann","sequence":"first","affiliation":[{"name":"TA Inflammation, Dermatology Boehringer Ingelheim International GmbH  Ingelheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Hofmann","sequence":"additional","affiliation":[{"name":"TA Inflammation, Dermatology Boehringer Ingelheim International GmbH  Ingelheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen R.","family":"Chiu","sequence":"additional","affiliation":[{"name":"Epidemiology Boehringer Ingelheim International GmbH  Ridgefield Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3388"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14386"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jvc2.113"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00654-z"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12070"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12863"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-021-00493-0"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/11586900-000000000-00000"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/PTT.S181808"},{"key":"e_1_2_12_11_1","unstructured":"Orphanet.Generalized pustular psoriasis. 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