{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:55:26Z","timestamp":1792468526089,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007631","name":"Chungnam National University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007631","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alopecia areata (AA) is a T\u2010cell\u2010mediated autoimmune disease that causes chronic, relapsing hair loss; however, its precise pathogenesis remains to be elucidated. Recent studies have provided compelling evidence of crosstalk between inflammasomes and mitophagy\u2014a process that contributes to the removal of damaged mitochondria. Our previous studies showed that the NLR family pyrin domain containing 3 (NLRP3) inflammasome is important for eliciting and progressing inflammation in AA. In this study, we detected mitochondrial DNA damage in AA\u2010affected scalp tissues and IFN\u03b3 and poly(I:C) treated outer root sheath (ORS) cells. In addition, IFN\u03b3 and poly(I:C) treatment increased mitochondrial reactive oxygen species (ROS) levels in ORS cells. Moreover, we showed that mitophagy induction alleviates IFN\u03b3 and poly(I:C)\u2010induced NLRP3 inflammasome activation in ORS cells. Lastly, PTEN\u2010induced kinase 1 (PINK1) knockdown increased NLRP3 inflammasome activation, indicating that PINK1\u2010mediated mitophagy plays a critical role in NLRP3 inflammasome activation in ORS cells. This study supports previous studies showing that oxidative stress disrupts immune privilege status and promotes autoimmunity in AA. The results emphasize the significance of crosstalk between mitophagy and inflammasomes in the pathogenesis of AA. Finally, mitophagy factors regulating mitochondrial dysfunction and inhibiting inflammasome activation could be novel therapeutic targets for AA.<\/jats:p>","DOI":"10.1111\/exd.14844","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T09:19:15Z","timestamp":1685697555000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The crosstalk between\n                    <scp>PTEN<\/scp>\n                    \u2010induced kinase 1\u2010mediated mitophagy and the inflammasome in the pathogenesis of alopecia areata"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7465-5243","authenticated-orcid":false,"given":"Jung\u2010Min","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Dermatology, School of Medicine Chungnam National University  Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine Chungnam National University  Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5040-3102","authenticated-orcid":false,"given":"Mi Soo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dankook University Hospital  Cheonan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine Chungnam National University  Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongkyun","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine Chungnam National University  Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u2010Eun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine Chungnam National University  Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Joon","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine Chungnam National University  Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9341-6491","authenticated-orcid":false,"given":"Chang Deok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine Chungnam National University  Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanseul","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9205-1785","authenticated-orcid":false,"given":"Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine Chungnam National University  Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2019.31.4.387"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12010135"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14753"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13814"},{"key":"e_1_2_11_6_1","first-page":"43","article-title":"Oxidative stress and alopecia areata","volume":"8","author":"Prie BE","year":"2015","journal-title":"J Med 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