{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:07:50Z","timestamp":1747184870657,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pellino\u20101 plays a crucial role in cellular proliferation and regulates inflammatory processes. This study investigated Pellino\u20101 expression patterns and their relationship with CD4<jats:sup>+<\/jats:sup> T\u2010cell subsets in psoriasis patients. Group 1 comprised primarily biopsied psoriasis lesions from 378 patients, multiplex\u2010immunostained for Pellino\u20101, CD4 and representative T helper (Th) cells (T\u2010bet [Th1], GATA3 [Th2], and ROR\u03b3t [Th17] and regulatory T cell [FoxP3] markers). Ki\u201067 labeling was evaluated in the epidermis. Group 2 comprised 43 Pellino\u20101\u2010positive cases immunostained for Pellino\u20101 in both lesion and non\u2010lesion skin biopsy samples. Five normal skin biopsies served as controls. Among 378 psoriasis cases, 293 (77.5%) were positive for Pellino\u20101 in the epidermis. Pellino\u20101\u2010positivity was higher in psoriasis lesions than in non\u2010lesions and normal skin (52.55% vs. 40.43% vs. 3.48%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; H\u2010score, 72.08 vs. 47.55 vs. 4.40, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively). Pellino\u20101\u2010positive cases also had a significantly higher Ki\u201067 labeling index (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Epidermal Pellino1\u2010positivity was significantly associated with higher ROR\u03b3t<jats:sup>+<\/jats:sup> (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) and FoxP3<jats:sup>+<\/jats:sup> (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) CD4<jats:sup>+<\/jats:sup> T cell ratios but not T\u2010bet<jats:sup>+<\/jats:sup> and GATA3<jats:sup>+<\/jats:sup> CD4<jats:sup>+<\/jats:sup> T cell ratios. Among the CD4<jats:sup>+<\/jats:sup>Pellino\u20101<jats:sup>+<\/jats:sup> T\u2010cell subsets, the CD4<jats:sup>+<\/jats:sup>Pellino\u20101<jats:sup>+<\/jats:sup>ROR\u03b3t<jats:sup>+<\/jats:sup> ratio was significantly associated with epidermal Pellinio\u20101 expression (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Pellino\u20101 expression is thus increased in psoriasis lesions and associated with increased epidermal proliferation and CD4<jats:sup>+<\/jats:sup> T\u2010cell subset infiltration, especially Th17 cells. This suggests that Pellino\u20101 could be a therapeutic target that simultaneously regulates psoriasis epidermal proliferation and immune interactions.<\/jats:p>","DOI":"10.1111\/exd.14852","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T07:34:43Z","timestamp":1686296083000},"page":"1476-1484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pellino\u20101 expression is associated with epidermal proliferation and enhanced Th17 cell infiltration in psoriatic lesions"],"prefix":"10.1111","volume":"32","author":[{"given":"Haeyon","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Pathology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora Jee\u2010Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kyungpook National University  Daegu Republic of Korea"},{"name":"Department of Pathology Kyungpook National University Chilgok Hospital  Daegu Republic of Korea"},{"name":"BK21 Four Program, School of Medicine Kyungpook National University  Daegu Republic of Korea"},{"name":"Clinical Omics Institute, Kyungpook National University  Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiwon","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Pathology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"},{"name":"Asan Institute for Life Science, University of Ulsan College of Medicine Asan Medical Center  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Samsung Medical Center Sungkyunkwan University School of Medicine  Suwon Republic of Korea"},{"name":"Research Institute, Curogen Co., Ltd.  Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Kwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Samsung Medical Center Sungkyunkwan University School of Medicine  Suwon Republic of Korea"},{"name":"Research Institute, Curogen Co., Ltd.  Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010In","family":"Maeng","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Catholic University of Daegu  Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0412-8709","authenticated-orcid":false,"given":"Heounjeong","family":"Go","sequence":"additional","affiliation":[{"name":"Department of Pathology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of 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