{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:56:57Z","timestamp":1790261817339,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T00:00:00Z","timestamp":1687651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dupilumab, blocking IL\u20104 and IL\u201013 signals, improves atopic dermatitis and Quality of Life but might be also associated with the occurrence of ocular adverse events (OAEs). The main objective of our prospective study was to characterize the cytokine and chemokine profile in the tear fluid of dupilumab\u2010treated patients with moderate\u2010to\u2010 severe atopic dermatitis and to identify biomarkers predicting the occurrence of ocular adverse events. Patients with moderate\u2010to\u2010severe AD underwent dermatological and ophthalmological evaluation at the baseline (T0) and week 16 or at the time of an eventual ocular adverse events (T1). A multiplex immunoassay measuring multiple cytokines and chemokines in the tear fluid extracted during ocular examination at both T0 and T1 was performed. Thirty\u2010nine patients with moderate\u2010to\u2010severe AD and treated with dupilumab were included in the study. Baseline tear fluid levels revealed a significantly higher concentration of type 2 cytokines and chemokines in AD patients than healthy controls. The occurrence of ocular adverse events during dupilumab therapy was associated with a significant increase of IL\u201033 tear fluid levels and a significantly lower tear break\u2010up time, this latter also identified as predictive factor. Our findings suggest that the ophthalmological examination should be considered a valid support to identify patients at risk of developing OAEs and to provide their appropriate management.<\/jats:p>","DOI":"10.1111\/exd.14859","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T06:38:47Z","timestamp":1687761527000},"page":"1531-1537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Dupilumab\u2010associated ocular adverse events are predicted by low tear break\u2010up time and correlate with high <scp>IL<\/scp>\u201033 tear concentrations in patients with atopic dermatitis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6739-0387","authenticated-orcid":false,"given":"A.","family":"Chiricozzi","sequence":"first","affiliation":[{"name":"Dermatologia Dipartimento di Medicina e Chirurgia Traslazionale Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"UOC di Dermatologia Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli\u2013IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2087-7526","authenticated-orcid":false,"given":"L.","family":"Di\u00a0Nardo","sequence":"additional","affiliation":[{"name":"Dermatologia Dipartimento di Medicina e Chirurgia Traslazionale Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"UOC di Dermatologia Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli\u2013IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Gori","sequence":"additional","affiliation":[{"name":"Dermatologia Dipartimento di Medicina e Chirurgia Traslazionale Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"UOC di Dermatologia Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli\u2013IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Dermatologia Dipartimento di Medicina e Chirurgia Traslazionale Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"UOC di Dermatologia Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli\u2013IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Dermatologia Dipartimento di Medicina e Chirurgia Traslazionale Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"UOC di Dermatologia Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. 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