{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T22:34:27Z","timestamp":1761172467523,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703097"],"award-info":[{"award-number":["81703097"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tapinarof is an aryl hydrocarbon receptor (AHR) ligand which is used to treat plaque psoriasis in adults. However, the underlying mechanism is not yet fully understood. In this study, we applied two of the most studied psoriasis mouse models: topical application of imiquimod (IMQ) and subcutaneous injection of IL\u201023. Although both models successfully induced psoriasis\u2010like lesions in mice, tapinarof had a completely opposite effect on the two models. Tapinarof decreased the expression of multiple essential cytokines involved in the pathological IL\u201023\/IL\u201017\/IL\u201022 axis and ameliorated IMQ\u2010induced psoriatic dermatitis, inhibiting keratinocyte proliferation and abnormal differentiation. However, in the IL\u201023\u2010injection\u2010model, tapinarof instead aggravated the disease. Here, tapinarof increased epidermal thickness and differentiated epidermal dysplasia in mice. Our data suggest that tapinarof may have different effects on varied types of psoriasis.<\/jats:p>","DOI":"10.1111\/exd.14862","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T19:50:30Z","timestamp":1687636230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The opposite effect of tapinarof between IMQ and IL\u201023 induced psoriasis mouse models"],"prefix":"10.1111","volume":"33","author":[{"given":"Xingyu","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences Fudan University  Shanghai China"},{"name":"Institute for Six\u2010Sector Economy Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruomei","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxue","family":"Tian","sequence":"additional","affiliation":[{"name":"Greater Bay Area Institute of Precision Medicine (Guangzhou), School of Life Sciences Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Hochgerner","sequence":"additional","affiliation":[{"name":"Greater Bay Area Institute of Precision Medicine (Guangzhou), School of Life Sciences Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences Fudan University  Shanghai 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