{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:20:51Z","timestamp":1787998851650,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pyoderma gangrenosum (PG) is an autoinflammatory disorder typically characterized by progressive ulcers with dense neutrophilic infiltrates in the absence of infectious causes. The chronic nature of this disease significantly impacts the patients' quality of life (QoL). Yet there is currently a dearth of information in the literature regarding standardised treatment guidelines and the impact of PG on patients' QoL. We conducted a literature search on PubMed using the terms \u201cpyoderma gangrenosum\u201d AND \u201cquality of life.\u201d We identified nine relevant articles that provide insight into which domains are affected and what treatment can improve QoL. The most common domains involved are physical, emotional, and psychological. Patients tend to feel depressed\/anxious, isolated, and embarrassed secondary to PG manifestations. Comorbidities such as Crohn's disease, monoclonal gammopathy of dermatologic significance, and ulcerative colitis can worsen the impact on these patients' QoL. Pain is also a significant contributor to decreasing patients' QoL. Treatments such as topical steroids, adalimumab, and canakinumab may help improve QoL scores. We believe this information can help clinicians guide the care of patients with PG and highlight the need for more studies and clinical trials focusing on PG treatments' impact on QoL.<\/jats:p>","DOI":"10.1111\/exd.14876","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T03:19:38Z","timestamp":1688959178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pyoderma gangrenosum and impact on quality of life: A narrative review"],"prefix":"10.1111","volume":"33","author":[{"given":"Stephanie N.","family":"Sanchez\u2010Melendez","sequence":"first","affiliation":[{"name":"Department of Dermatology Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Ponce Health Sciences University, School of Medicine  Ponce Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5141-5017","authenticated-orcid":false,"given":"Rhea","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Dermatology Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payal M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Cutaneous Biology Research Center Massachusetts General Hospital, Harvard University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2448-8285","authenticated-orcid":false,"given":"Sofia","family":"Milosavljevic","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts 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