{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:07:57Z","timestamp":1747184877600,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Healthcare professionals (HCPs) should strive to create the maximum value for their patients in which value is defined as the patient\u2010relevant health outcomes achieved per costs made. However, currently it remains difficult to determine which outcomes matter to an individual psoriasis patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To define outcome profiles, or so called \u2018patient value profiles\u2019, within a cohort of psoriasis patients that can be translated to daily practice to increase value for the individual patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hierarchical clustering on principal components (HCPC) was used to identify groups of patients sharing the same profile within an outcome ranking exercise. Once the clusters were defined, their characterization was provided based on a V\u2010test. In a final step, a multi\u2010class decision tree (MDT) based on relevant socio\u2010demographic and clinical variables was built to allocate patients to a cluster.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the ranking exercise 120 patients participated. The median age was 50.0 (IQR 25.0) years and 36.7% were female. Median PASI score was 2.4 (IQR 5.2) and median duration of psoriasis was 17.0 (IQR 20.0) years. Primary treatment varied from topicals to biologicals. We found three distinct patient value profiles in this cohort (<jats:italic>QoL<\/jats:italic>, <jats:italic>cost<\/jats:italic> and <jats:italic>treatment<\/jats:italic>). A MDT was built which had an accuracy of 64%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found three distinct patient value profiles in a cohort of psoriasis patients and patients can be easily assigned to one of these profiles based on a MDT. HCPs can use these profiles to steer psoriasis management accordingly allowing for a more goal\u2010orientated approach.<\/jats:p><\/jats:sec>","DOI":"10.1111\/exd.14906","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T07:14:55Z","timestamp":1691738095000},"page":"1815-1822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Determining patient value profiles in psoriasis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5355-6235","authenticated-orcid":false,"given":"N. T.","family":"Hilhorst","sequence":"first","affiliation":[{"name":"Dermatology Research Unit Ghent University  Ghent Belgium"},{"name":"Department of Dermatology Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Abatih","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics, Computer Sciences and Statistics Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Deprez","sequence":"additional","affiliation":[{"name":"Dermatology Research Unit Ghent University  Ghent Belgium"},{"name":"Department of Dermatology Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L. W.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Dermatology Research Unit Ghent University  Ghent Belgium"},{"name":"Department of Dermatology Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Hoorens","sequence":"additional","affiliation":[{"name":"Dermatology Research Unit Ghent University  Ghent Belgium"},{"name":"Department of Dermatology Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"volume-title":"Redefining Health Care: Creating Value\u2010Based Competition on Results","year":"2006","author":"Porter ME","key":"e_1_2_12_2_1"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMP1011024"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.743180"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1087-0024.2003.09110.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.07.064"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMADERMATOL.2022.1756"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/JDV.18696"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15324"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-017-0205-2"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1117566"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/17843286.2020.1750747"},{"volume-title":"Principal Component Methods\u2013Hierarchical Clustering\u2013Partitional Clustering: why Would we Need to Choose for Visualizing Data?","year":"2010","author":"Husson F","key":"e_1_2_12_13_1"},{"volume-title":"R: a language and environment for statistical computing","year":"2023","author":"R Core Team","key":"e_1_2_12_14_1"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781315139470"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214439"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86703-3"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12913-019-4081-6"},{"issue":"1","key":"e_1_2_12_19_1","first-page":"46","article-title":"Goal\u2010oriented medical care","volume":"23","author":"Mold J","year":"1991","journal-title":"Fam Med"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1113631"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-022-07533-1"},{"issue":"12","key":"e_1_2_12_22_1","first-page":"30","article-title":"Efficacy, safety, and out\u2010of\u2010pocket costs are the most important factors to patients in choosing a psoriasis therapy","volume":"7","author":"Secrest AM","year":"2014","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12372"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.08.023"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.06.018"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T03:38:11Z","timestamp":1743910691000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,11]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/exd.14906"],"URL":"https:\/\/doi.org\/10.1111\/exd.14906","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"type":"print","value":"0906-6705"},{"type":"electronic","value":"1600-0625"}],"subject":[],"published":{"date-parts":[[2023,8,11]]},"assertion":[{"value":"2023-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}