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However, the precise mechanism underlying the comorbidity of psoriasis and anxiety is unknown. Also, whether the social avoidance phenomenon seen in human patients also exists in psoriasis\u2010like animal models remains unknown. In the present study, anxiety\u2010like behaviours and social avoidance\u2010like behaviours were observed in an imiquimod\u2010induced psoriasis\u2010like C57\u2010BL6 mouse model along with typical psoriasis\u2010like dermatitis and itch\u2010like behaviours. The 11.7T resting\u2010state functional magnetic resonance imaging showed differences in brain regions between the model and control group, and voxel\u2010based morphometry showed that the grey matter volume changed in the basal forebrain region, anterior commissure intrabulbar and striatum in the psoriasis\u2010like mice. Seed\u2010based resting state functional connectivity analysis revealed connectivity changes in the amygdala, periaqueductal gray, raphe nuclei and lateral septum. We conclude that the imiquimod\u2010induced psoriasis\u2010like C57\u2010BL6 mouse model is well suited for mechanistic studies and for performing preclinical therapeutic trials for treating anxiety and pathological social avoidance in psoriasis patients.<\/jats:p>","DOI":"10.1111\/exd.14914","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T08:15:17Z","timestamp":1692951317000},"page":"1900-1914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Resting\u2010state f\n                    <scp>MRI<\/scp>\n                    reveals changes within the anxiety and social avoidance circuitry of the brain in mice with psoriasis\u2010like skin lesions"],"prefix":"10.1111","volume":"32","author":[{"given":"Teng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Institute of Acupuncture Research, Institutes of Integrative Medicine, Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9908-1020","authenticated-orcid":false,"given":"Sheng\u2010Jie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Science and Technology for Brain\u2010Inspired Intelligence, Zhongshan Hospital, Human Phenome Institute, Key Laboratory of Computational Neuroscience and Brain\u2010Inspired Intelligence, Ministry of Education Fudan University  Shanghai 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