{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:12:30Z","timestamp":1789567950618,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sweet syndrome (SS) as a prototypic neutrophilic dermatosis (NDs) shares certain clinical and histologic features with monogenic auto\u2010inflammatory disorders in which interleukin (IL)\u20101 cytokine family members play an important role. This has led to the proposal that NDs are polygenic auto\u2010inflammatory diseases and has fuelled research to further understand the role of IL\u20101 family members in the pathogenesis of NDs. The aim of this study was to characterise the expression of the IL\u20101 family members IL\u20101\u03b2, IL\u201036\u03b3, IL\u201033 and IL\u20101R3 (IL\u20101RaP) in SS. The expression profile of IL\u20101\u03b2, IL\u201033, IL\u201036\u03b3 and their common co\u2010receptor IL\u20101R3 was analysed by immunohistochemistry, in situ hybridisation and double immunofluorescence (IF) in healthy control skin (HC) and lesional skin samples of SS. Marked overexpression of IL\u20101\u03b2 in the dermis of SS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and a non\u2010significant increase in dermal (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.087) and epidermal (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.345) IL\u201036\u03b3 expression compared to HC was observed. Significantly increased IL\u20101R3 expression within the dermal infiltrate of SS skin samples (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02) was also observed, whereas no difference in IL\u201033 expression was found between SS and HC (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.7139). In situ hybridisation revealed a good correlation between gene expression levels and the above protein expression levels. Double IF identifies neutrophils and macrophages as the predominant sources of IL\u20101\u03b2. This study shows that IL\u20101\u03b2 produced by macrophages and neutrophils and IL\u20101R3 are significantly overexpressed in SS, thereby indicating a potential pathogenic role for this cytokine and receptor in SS.\n                  <\/jats:p>","DOI":"10.1111\/exd.14916","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T07:59:17Z","timestamp":1695110357000},"page":"1915-1923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Characterisation of\n                    <scp>IL<\/scp>\n                    \u20101 family members in Sweet syndrome highlights the overexpression of\n                    <scp>IL<\/scp>\n                    \u20101\u03b2 and\n                    <scp>IL\u20101R3<\/scp>\n                    as possible therapeutic targets"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5238-2336","authenticated-orcid":false,"given":"Laura","family":"Calabrese","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital LMU  Munich Germany"},{"name":"Institute of Dermatology Catholic University of the Sacred Heart  Rome Italy"},{"name":"Dermatology Unit, Department of Medical, Surgical and Neurological Sciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ney","sequence":"additional","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7061-4508","authenticated-orcid":false,"given":"Rui","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital LMU  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Moltrasio","sequence":"additional","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo V.","family":"Marzano","sequence":"additional","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Kerl","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital LMU  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia\u2010Charlotte","family":"Stadler","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital LMU  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi K.","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital LMU  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars E.","family":"French","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital LMU  Munich Germany"},{"name":"Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, Miller School of Medicine University of Miami  Miami Florida 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