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This growth activity is partly influenced by growth factors (GFs) that play an important role in cell growth and inflammation during the plaque development. In this study, we identified potential GFs in CE skin and predicted their regulatory functions and biological activity in mediating transcripts in the plaques. Samples of uninvolved skin (UN skin) and CE skin were biopsied from patients with psoriasis vulgaris for RNA\u2010sequencing analysis in order to identify differentially expressed genes (DEGs). Our finding revealed that epidermal growth factor (EGF), fibroblast growth factor (FGF), platelet\u2010derived growth factor (PDGF) and hepatocyte growth factor (HGF) signalling were enriched by CE\/UN skin\u2010derived DEGs. Additionally, several EGFR ligands, namely EGF, heparin\u2010binding EGF like growth factor (HB\u2010EGF), amphiregulin (AREG) and transforming growth factor (TGF)\u2010\u03b1, as well as TGF\u2010\u03b21, TGF\u2010\u03b22, vascular endothelial growth factor\u2010A, FGFs, PDGF\u2010B and HGF, were predicted to be GF regulators. The regulatory pattern and biological activity of these GF regulators on mediating the CE\/UN skin\u2010derived DEGs was demonstrated. This study provides a novel hypothesis regarding the overall regulatory function of GFs, which appear to modulate the expression of the transcripts involved in inflammation and growth in the CE skin. In addition, some GFs may exert anti\u2010inflammatory effects. Further investigations on the mechanisms underlying this regulation may contribute to a deeper understanding of psoriasis and the identification of potential therapeutic targets for patients with psoriasis.<\/jats:p>","DOI":"10.1111\/exd.14918","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T08:41:16Z","timestamp":1693816876000},"page":"1924-1934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploring the role of growth factors as potential regulators in psoriatic plaque formation"],"prefix":"10.1111","volume":"32","author":[{"given":"Suphagan","family":"Boonpethkaew","sequence":"first","affiliation":[{"name":"Division of Dermatology, Chulabhorn International College of Medicine Thammasat University  Pathum Thani Thailand"},{"name":"Thammasat University  Chonburi 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