{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:59Z","timestamp":1787014199991,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81000696"],"award-info":[{"award-number":["81000696"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472884"],"award-info":[{"award-number":["81472884"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Systemic lupus erythematosus (SLE) is an autoimmune disease in which defective T cells, immune complex deposition and other immune system alterations contribute to pathological changes of multiple organ systems. The vitamin D metabolite c is a critical immunomodulator playing pivotal roles in the immune system. Epidemiological evidence indicates that vitamin D deficiency is correlated with the severity of SLE. Our aim is to investigate the effects of 1,25(OH)2D3 (VitD3) on the activation of myeloid dendritic cells (mDCs) by autologous DNA\u2010containing immune complex (DNA\u2010ICs), and the effects of VitD3 on immune system balance during SLE. We purified DNA\u2010ICs from the serum of SLE patients and isolated mDCs from normal subjects. In vitro studies showed that DNA\u2010ICs were internalized and consumed by mDCs. VitD3 blocked the effects of DNA\u2010ICs on RelB, IL\u201010 and TNF\u2010\u03b1 in mDCs. Further analysis indicated that DNA\u2010ICs stimulated histone acetylation in the RelB promoter region, which was inhibited by VitD3. Knockdown of the histone deacetylase 3 gene (HDAC3) blocked these VitD3\u2010mediated effects. Co\u2010culture of mDCs and CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells showed that VitD3 inhibited multiple processes mediated by DNA\u2010ICs, including proliferation, downregulation of IL\u201010, TGF\u2010\u03b2 and upregulation of TNF\u2010\u03b1. Moreover, VitD3 could also reverse the effects of DNA\u2010IC\u2010induced imbalance of CD4\n                    <jats:sup>+<\/jats:sup>\n                    \u2009CD127\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u2009Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    T cells and CD4\n                    <jats:sup>+<\/jats:sup>\n                    \u2009IL17\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Taken together, our results indicated that autologous DNA\u2010ICs stimulate the activation of mDCs in the pathogenesis of SLE, and VitD3 inhibits this stimulatory effects of DNA\u2010ICs by negative transcriptional regulation of RelB gene and maintaining the Treg\/Th17 immune cell balance. These results suggest that vitamin D may have therapeutic value for the treatment of SLE.\n                  <\/jats:p>","DOI":"10.1111\/exd.14926","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T08:09:30Z","timestamp":1694592570000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Vitamin\n                    <scp>D3<\/scp>\n                    mitigates autoimmune inflammation caused by activation of myeloid dendritic cells in\n                    <scp>SLE<\/scp>"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3047-7139","authenticated-orcid":false,"given":"Mingfang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology The Third Affiliated Hospital of Chongqing Medical University  Chongqing China"},{"name":"Department of Dermatology, Southwest Hospital Army Medical University (Third Military Medical University)  Chongqing China"},{"name":"Department of Dermatology The Third Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Third Affiliated Hospital of Chongqing Medical University  Chongqing China"},{"name":"Department of Dermatology, Southwest Hospital Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanchuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Southwest Hospital Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Ni","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Zou","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Southwest Hospital Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Third Affiliated Hospital of Chongqing Medical University  Chongqing China"},{"name":"Department of Dermatology, Southwest Hospital Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Digital Medicine, College of Biomedical Engineering and Medical Imaging Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9686-3043","authenticated-orcid":false,"given":"Na","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Third Affiliated Hospital of Chongqing Medical University  Chongqing China"},{"name":"Department of Dermatology, Southwest Hospital Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102359"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2020.1832464"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.569234"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3638562"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13041"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2007.01.017"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002821"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2022.102856"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.12932\/AP-070919-0639"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06175"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1178331"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5045248"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01957"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37968"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4053038"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6047085"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.07.007"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2019.102392"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2000.4998"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2530-5"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2014.10.011"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.05.044"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.068"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.11.001"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1720902"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1998.0231"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1064890"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23025"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.03.004"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23052505"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2007.10.005"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.66.2.205"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2006.01849.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel061"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh160"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8101291"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2020.11.001"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12806"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109601"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12532"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0218-0"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.03.048"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-023-00944-2"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2020.1862753"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1450351"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2007.01.034"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506516102"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm913"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00642"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2022.102870"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2019.101330"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2016.04.010"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:13:44Z","timestamp":1761110024000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,13]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/exd.14926"],"URL":"https:\/\/doi.org\/10.1111\/exd.14926","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,13]]},"assertion":[{"value":"2023-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14926"}}