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Intermittent fasting (IF) has exhibited various beneficial effects in reducing inflammation, resisting oxidative stress and slowing ageing, as well as losing weight. A form of IF known as time\u2010restricted feeding (TRF) restricts daily caloric intake within 4\u20138\u2009h. Nonetheless, the advantageous impacts of TRF on psoriasis still require further verification. We measured the acanthosis in Imiquimod (IMQ)\u2010induced psoriasis mice and evaluated their pathological phenotypes. Our study examined the effects of a 2\u2010week TRF on body weight and metabolic parameters. The subsets of T cells in spleens and skin lesions were accessed by flow cytometry. Cytokines and senescence\u2010associated genes were evaluated by immunofluorescence and RT\u2010qPCR. RNA sequencing was conducted on skin lesions. According to our findings, a 2\u2010week TRF attenuates psoriasis\u2010like lesions in mice with reduced inflammatory cytokines and mitigated immunosenescence. TRF increased the counts of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>reg<\/jats:sub>\n                    cells in skin lesions while reducing the counts of Th\n                    <jats:sub>2<\/jats:sub>\n                    and Th\n                    <jats:sub>17<\/jats:sub>\n                    cells in spleens. Furthermore, the administration of TRF resulted in a decrease in the population of CD4\n                    <jats:sup>+<\/jats:sup>\n                    senescent T cells in both the dermis and spleens, concomitant with the expression of senescence\u2010associated genes in spleen CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells. The outcomes mentioned above provide valuable evidence in support of TRF for the management of psoriasis.\n                  <\/jats:p>","DOI":"10.1111\/exd.14932","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T02:35:46Z","timestamp":1695177346000},"page":"2000-2011","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A 2\u2010week time\u2010restricted feeding attenuates psoriasis\u2010like lesions with reduced inflammatory cytokines and immunosenescence in mice"],"prefix":"10.1111","volume":"32","author":[{"given":"Yiran","family":"Chen","sequence":"first","affiliation":[{"name":"Hospital for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"},{"name":"Key Laboratory of Basic and Translational Research on Immune\u2010Mediated Skin Diseases Chinese Academy of Medical Sciences  Nanjing China"},{"name":"Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs Chinese Academy of Medical Sciences and Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Xiangya Hospital of Central South University Hunan Key Laboratory of Medical Epigenomics  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Xiangya Hospital of Central South University Hunan Key Laboratory of Medical Epigenomics  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Xiangya Hospital of Central South University Hunan Key Laboratory of Medical Epigenomics  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Xiangya Hospital of Central South University Hunan Key Laboratory of Medical Epigenomics  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Xiangya Hospital of Central South University Hunan Key Laboratory of Medical Epigenomics  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Xiangya Hospital of Central South University Hunan Key Laboratory of Medical Epigenomics  Changsha Hunan 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