{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:29:41Z","timestamp":1793255381505,"version":"4.5.0"},"reference-count":10,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Atypical pigmented facial lesions (aPFLs)\u2014including lentigo maligna (LM) and lentigo maligna melanoma (LMM), solar lentigo (SL), pigmented actinic keratosis (PAK), atypical nevi (AN), seborrheic keratosis (SK) and lichen planus\u2010like keratosis (LPLK)\u2014can exhibit clinical and dermoscopic overlapping features. We aimed to investigate if and how 14 dermoscopic features suggestive for the aforementioned aPFLs vary according to six facial sites among 1197 aPFLs cases (excised to rule out malignancy) along with lesion and patients' metadata. According to distribution and association analysis, aPFLs on the forehead of a male patient aged\u2009&gt;\u200969\u2009years displaying the\n                    <jats:italic>obliterated follicular openings<\/jats:italic>\n                    pattern, appear to be more at risk of malignancy. Of converse, aPFLs of the orbital\/cheek\/nose area with evident and regular follicular openings with diameter\u2009&lt;\u200910\u2009mm in a female aged below 68 are probably benign. The\n                    <jats:italic>obliterated follicular openings<\/jats:italic>\n                    ,\n                    <jats:italic>keratin plugs<\/jats:italic>\n                    ,\n                    <jats:italic>evident and regular follicular openings and target\u2010like pattern<\/jats:italic>\n                    features differed significantly among six facial areas in all aPFLs cases. Lesion of the nose may show both features suggestive of malignancy and benignity (e.g. many SL and PAK may display\n                    <jats:italic>target\u2010like pattern<\/jats:italic>\n                    and some LM\/LMM cases display\n                    <jats:italic>keratin plugs<\/jats:italic>\n                    and\n                    <jats:italic>evident and follicular openings<\/jats:italic>\n                    ), making these features less specific.\n                  <\/jats:p>","DOI":"10.1111\/exd.14941","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T22:58:28Z","timestamp":1695941908000},"page":"2166-2172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Dermoscopy of atypical pigmented lesions of the face: Variation according to facial areas"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6691-4310","authenticated-orcid":false,"given":"Linda","family":"Tognetti","sequence":"first","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurosciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Cartocci","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurosciences University of Siena  Siena Italy"},{"name":"Department of Medical Biotechnologies University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Cinotti","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurosciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"D'Onghia","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurosciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"\u017bychowska","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institute of Medical Sciences Medical College of Rzeszow University  Rzesz\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Moscarella","sequence":"additional","affiliation":[{"name":"Dermatology Unit University of Campania Luigi Vanvitelli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3186-2861","authenticated-orcid":false,"given":"Emi","family":"Dika","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Experimental, Diagnostic and Specialty Medicine (DIMES) University of Bologna  Bologna Italy"},{"name":"Dermatology IRCCS Azienda Ospedaliero Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7088-9077","authenticated-orcid":false,"given":"Francesca","family":"Farnetani","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8221-6694","authenticated-orcid":false,"given":"Stefania","family":"Guida","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia  Modena Italy"},{"name":"Dermatology Clinic IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Paoli","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Department of Dermatology and Venereology Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimilios","family":"Lallas","sequence":"additional","affiliation":[{"name":"First Department of Dermatology Aristotle University  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danica","family":"Tiodorovic","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Medical Faculty University of Nis  Nis Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignazio","family":"Stanganelli","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit Scientific Institute of Romagna for the Study of Cancer, IRCCS, IRST  Meldola Italy"},{"name":"Department of Dermatology University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia  Modena Italy"},{"name":"Centro Oncologico ad Alta Tecnologia Diagnostica Azienda Unit\u00e0 Sanitaria Locale, IRCCS di Reggio Emilia  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Suppa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles  Brussels Belgium"},{"name":"Groupe d'Imagerie Cutan\u00e9e Non\u2010Invasive Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie  Paris France"},{"name":"Department of Dermatology Institut Jules Bordet  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Zalaudek","sequence":"additional","affiliation":[{"name":"Dermatology Clinic Ospedale di Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Argenziano","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institute of Medical Sciences Medical College of Rzeszow University  Rzesz\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Luc","family":"Perrot","sequence":"additional","affiliation":[{"name":"Dermatology Unit University Hospital of St\u2010Etienne  Saint Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Rubegni","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Cataldo","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies University of Siena  Siena 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/7178305"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.01.030"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/tmj.2022.0456"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19360"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40136-018-0199-z"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2013.05.030"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.0803a10"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.0904a08"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.06.085"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16847"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T10:39:58Z","timestamp":1702809598000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,28]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/exd.14941"],"URL":"https:\/\/doi.org\/10.1111\/exd.14941","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,28]]},"assertion":[{"value":"2023-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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