{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:35:17Z","timestamp":1788388517318,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000054"],"award-info":[{"award-number":["32000054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170071"],"award-info":[{"award-number":["32170071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acne is a chronic disease that often persists for years. Skin microbial communities play an essential role in the development of acne. However, limited information is available about the dynamic patterns of skin microbiota in acne. This study aimed to characterize microbial community changes in skin pores and surfaces of acne patients with varying disease time. In this study, a total of 70 skin samples from 22 subjects were collected and sequenced using 16S rRNA amplicon sequencing. Although microbial compositions in skin pores were similar over time, significant differences in microbial structure were observed on the skin surface, with the dominance of <jats:italic>Cutibacterium<\/jats:italic> in the first 3\u2009years and replacement by <jats:italic>Staphylococcus<\/jats:italic> in 4\u20136\u2009years. <jats:italic>Lactobacillus<\/jats:italic> and <jats:italic>Acinetobacter<\/jats:italic> were more abundant in the normal group and continuingly decreased with disease time on the skin surface. Microbial networks further revealed substantial increases in microbial interactions in the 4\u20136\u2009years group in both skin surfaces and pores. These results demonstrate that the skin microbiota alters with the disease duration and may provide a potential guide in redirecting skin microbiota towards healthy states.<\/jats:p>","DOI":"10.1111\/exd.14951","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T12:20:13Z","timestamp":1697545213000},"page":"2102-2111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A cross\u2010sectional cohort study on the skin microbiota in patients with different acne durations"],"prefix":"10.1111","volume":"32","author":[{"given":"Lang","family":"Sun","sequence":"first","affiliation":[{"name":"Human Microbiome and Health Group, Department of Microbiology, School of Basic Medical Science Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqun","family":"Wang","sequence":"additional","affiliation":[{"name":"Human Microbiome and Health Group, Department of Microbiology, School of Basic Medical Science Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Fourth Hospital of Changsha  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Parasitology, School of Basic Medical Science Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Human Microbiome and Health Group, Department of Microbiology, School of Basic Medical Science Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(98)70442-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.10.033"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.190102"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.264"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00785-06"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03467.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18088"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-20-1-11"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.157"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.06.017"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-020-00531-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13988"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9010168"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18616"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14952"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-021-0647-1"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.21"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04214.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.078"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70206-8"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03685.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3869"},{"key":"e_1_2_10_24_1","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2023"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1219"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061217"},{"key":"e_1_2_10_27_1","unstructured":"OksanenJ SimpsonGL BlanchetFG et\u00a0al.Vegan: community ecology package.2022https:\/\/CRAN.R\u2010project.org\/package=vegan"},{"key":"e_1_2_10_28_1","unstructured":"ChenH.VennDiagram: generate high\u2010resolution venn and euler plots.2022https:\/\/CRAN.R\u2010project.org\/package=VennDiagram"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_10_30_1","first-page":"1","article-title":"The igraph software package for complex network research","volume":"1695","author":"Csardi G","year":"2006","journal-title":"Int J Complex Syst"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0558-5"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12253-y"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S379609"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm-21-1482"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-25436-3"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2537"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13296"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-139-8-1745"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00003-13"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17111870"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-91398-7"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-013-5394-8"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77790-9"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-4749-3-1"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3920\/BM2012.0060"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00392"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.705690"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000723"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.07.059"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S69135"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23092164"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/10799893.2020.1805626"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002606"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01043-13"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.01202-20"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.01.016"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.11.013"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T15:40:20Z","timestamp":1702827620000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,17]]},"references-count":56,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/exd.14951"],"URL":"https:\/\/doi.org\/10.1111\/exd.14951","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,17]]},"assertion":[{"value":"2023-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}