{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:40:57Z","timestamp":1785552057942,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cases of atopic dermatitis (AD)\u2010like rash induced by IL\u201017A inhibitor secukinumab treatment (SI\u2010AD) have been recently reported in psoriasis patients. To identify immune and inflammatory factors expression in SI\u2010AD. A panel of 15 immune and inflammatory factors in peripheral blood samples from various groups, including patients with patients with SI\u2010AD, psoriasis with secukinumab (S\u2010stable), advanced psoriasis patients (Advanced) and healthy controls (HC). Interleukin\u201010 (IL\u201010), IL\u20104 and IL\u201017A were detected in skin tissue biopsy samples by immunohistochemistry and real\u2010time quantitative polymerase chain reaction. The immunoglobulin E levels in the SI\u2010AD patients exceeded normal values. The IL\u201010 levels in SI\u2010AD patients were higher than those in S\u2010stable patients, advanced patients and HC. The IL\u20104 levels in SI\u2010AD patients were higher than that in S\u2010stable patients and HC. The IL\u201017A levels in SI\u2010AD patients were higher than those in advanced psoriasis patients and HC, but no significant differences were observed between SI\u2010AD patients and S\u2010stable patients. IL\u201010 and IL\u20104 levels were higher in AD\u2010like rashes than in healthy skin, while IL\u201017A did not differ significantly between the two. Upon discontinuing secukinumab, and switching to oral cyclosporine, antihistamines, Janus kinase 1 inhibitor and topical glucocorticoids, SI\u2010AD patients experienced significant improvement in their skin lesions. Upon reexamination, all 15 immune and inflammatory factors returned to normal levels. Immune shift from Th17 towards Th2 may occur in SI\u2010AD, as indicated by abnormal expression of multiple immune and inflammatory factors observed in peripheral blood and skin tissues.<\/jats:p>","DOI":"10.1111\/exd.14958","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T10:03:16Z","timestamp":1701079396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Development of IL\u201017A inhibitor\u2010induced atopic dermatitis\u2010like rash in psoriasis patients: Insights into immune shift"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6348-5750","authenticated-orcid":false,"given":"Qiuju","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology The First Affiliated Hospital of Guangxi Medical University  Nanning 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Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Baise People's Hospital  Baise China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huahui","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Baise People's Hospital  Baise China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunwei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology The First Affiliated Hospital of Guangxi Medical University  Nanning 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