{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T02:55:28Z","timestamp":1780368928390,"version":"3.54.1"},"reference-count":55,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T00:00:00Z","timestamp":1697846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the registration trial of risankizumab for patients with moderate\u2010to\u2010severe psoriasis in Japan, similar Psoriasis Area Severity Index (PASI) responses were observed for 75\u2009mg or 150\u2009mg risankizumab at most time points up to 52\u2009weeks, except for PASI 100 at week 16. The use of 75\u2009mg risankizumab offers an attractive option considering the high cost of risankizumab. However, it is unknown whether patients with mild\u2010to\u2010moderate psoriasis respond similarly, and the efficacy data of non\u2010Japanese patients is also lacking. We retrospectively included 30 consecutive Chinese patients receiving half\u2010dose (75\u2009mg) risankizumab as scheduled up to 52\u2009weeks. Compared with biologic\u2010experienced group, biologic\u2010naive group had a significantly higher PASI 50\/75\/90\/100 achievement (<jats:italic>p<\/jats:italic>\u2009=\u20090.0098\/0.0039\/0.0016\/0.0054) at week 52. PASI 50\/75\/90\/100 curves in biologic\u2010naive group (<jats:italic>p<\/jats:italic>\u2009=\u20090.0117\/0.0239\/0.0143\/0.0269) were also significantly higher when analysed generalized estimating equations (GEE) model. Though there was no statistically significant difference in terms of PASI 50\/75\/90\/100 responses at any time points between those with body weight \u2266 65\u2009kg and those &gt;65\u2009kg, a tendency of secondary failure was noted in those &gt;65\u2009kg from week 40 onwards. Patients who were both biologic\u2010naive and weighed \u2266 65\u2009kg achieved sustained PASI 50\/75\/90 responses from week 16\/28\/40 onwards, respectively, indicating that they could be considered as potential candidates for 75\u2009mg risankizumab. Though PASI 75 curve in patients without diabetes mellitus (DM) surpassed that in patient without DM, curves of other parameters did not reach significance when analysed by GEE model. There was no HBV, HCV or TB reactivation, nor other new safety signals during the 52\u2010week observational period. Providing risankizumab with flexible dosing options is beneficial in clinical practice considering the high cost of this medication.<\/jats:p>","DOI":"10.1111\/exd.14963","type":"journal-article","created":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T08:44:40Z","timestamp":1697877880000},"page":"2138-2148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Predictors for the effectiveness of 75\u2009mg risankizumab in treating psoriasis\u2014A real\u2010word evidence from a 52\u2010week retrospective study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9740-9720","authenticated-orcid":false,"given":"Chang\u2010Yu","family":"Hsieh","sequence":"first","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hsian","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1498-1474","authenticated-orcid":false,"given":"Tsen\u2010Fang","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAAD.2019.08.026"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S387759"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14890"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040622319843756"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14810"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/IJD.12879"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/JDV.18126"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/JDV.18825"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/S13555-019-0310-5"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/JDV.19236"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v102.685"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56110584"},{"issue":"4","key":"e_1_2_12_14_1","first-page":"412","article-title":"A review of clinical trials of biologic agents and small molecules for psoriasis in Asian subjects","volume":"151","author":"Tsai YC","year":"2016","journal-title":"G Ital Dermatol Venereol"},{"issue":"3","key":"e_1_2_12_15_1","first-page":"227","article-title":"New pharmacological strategies in rheumatic diseases","volume":"9","author":"Schiotis RE","year":"2016","journal-title":"J Med Life"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13197"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA1314258"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15655"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001510"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14941"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10688.x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.812010"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.DSI.2018.06.006"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.DSI.2016.05.004"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1468-3083.2011.04199.X"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/LIFE12122050"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/JDV.16564"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18333"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.01.041"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2020.1743175"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/S13555-022-00865-0"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.4103\/ds.ds_32_22"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.07.040"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAAD.2017.05.033"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAAD.2016.07.058"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/JDV.16181"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.4103\/ds.ds-d-22-00096"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/BJD.19570"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/JDV.18678"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/JDV.16521"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15378"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/DTH.15793"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/DTH.13323"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2023.2200870"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-022-00722-y"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-022-00795-x"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2022.2012567"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2022.2103538"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/LIFE12091412"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.06.883"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2021.1898528"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-049822"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18846"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-023-02568-0"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.4103\/ds.ds_18_22"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2022.09.023"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T15:39:56Z","timestamp":1702827596000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,21]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/exd.14963"],"URL":"https:\/\/doi.org\/10.1111\/exd.14963","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,21]]},"assertion":[{"value":"2023-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}