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However, their physiological functions have not been given sufficient attention by clinicians. IL\u201017s can protect the host from extracellular pathogens, maintain epithelial integrity, regulate cognitive processes and modulate adipocyte activity through distinct mechanisms. Here, we present a systematic review concerning the physiological functions of IL\u201017s. Our goal is not to negate the therapeutic effect of IL\u201017 antagonists, but to ensure their safe use and reasonably explain the possible adverse events that may occur in their application.<\/jats:p>","DOI":"10.1111\/exd.14964","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T07:33:37Z","timestamp":1698737617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Physiological roles of human interleukin\u201017 family"],"prefix":"10.1111","volume":"33","author":[{"given":"Yucong","family":"Liu","sequence":"first","affiliation":[{"name":"The Second School of Clinical Medicine Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Ouyang","sequence":"additional","affiliation":[{"name":"The Second School of Clinical Medicine Southern Medical University  Guangzhou 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