{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:36:23Z","timestamp":1773203783533,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009122","name":"Ministry of Higher Education and Scientific Research","doi-asserted-by":"publisher","award":["2022R1F1A1064387"],"award-info":[{"award-number":["2022R1F1A1064387"]}],"id":[{"id":"10.13039\/100009122","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Atopic dermatitis (AD) is a chronic, recurrent eczematous disorder with a complex pathophysiology caused by skin barrier abnormalities. Rosacea is a common chronic immune\u2010mediated inflammatory disorder that results in diminished skin barrier function. Reflectance confocal microscopy (RCM) is a non\u2010invasive method for visualizing the dynamic status of epidermal and upper dermal structures. In this study, we compared skin barrier permeability among normal, AD and rosacea groups. To assess skin barrier permeability, zinc was applied to lesional skin and the RCM reflectance intensity of zinc penetration was measured. Reflectance confocal microscopy revealed that the intensity in patients with rosacea and AD was higher than that in the normal group at depths of 8\u201324\u2009\u03bcm in both the face and forearm, which were considered as the stratum corneum (SC) and tight junction (TJ) level (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). When comparing AD and rosacea, the intensity of rosacea was higher than that of AD at a depth of 8\u2009\u03bcm in the face (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). The intensity of AD was higher than that of rosacea at a depth of 24\u2009\u03bcm (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009). This suggests that skin barrier permeability is increased in the upper epidermis of patients with AD and rosacea. On the face, patients with rosacea had more SC weakness than did those with AD, whereas patients with AD had more TJ weakness than those with rosacea.\n                  <\/jats:p>","DOI":"10.1111\/exd.14971","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T09:15:04Z","timestamp":1698830104000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Zinc penetration through the skin barrier in atopic dermatitis and rosacea using reflectance confocal microscopy"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0085-9566","authenticated-orcid":false,"given":"Hye\u2010Jin","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Dermatology Kyung Hee University College of Medicine Kyung Hee University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9834-7931","authenticated-orcid":false,"given":"Min Kyung","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyung Hee University College of Medicine Kyung Hee University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16934"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.02.025"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12251"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2021.10.010"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.20.002258"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/51\/6\/008"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cap.2012.04.013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-87346-0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000108101"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2021.04.007"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.17.3069"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30341-9"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14792"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58718-9"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:12:09Z","timestamp":1761109929000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/exd.14971"],"URL":"https:\/\/doi.org\/10.1111\/exd.14971","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"2023-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14971"}}