{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:51:27Z","timestamp":1777704687341,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>There is evidence of a link between disease activity in vitiligo and clinical visible signs such as confetti\u2010like depigmentation, Koebner phenomenon and hypochromic areas\/borders. Despite its established value, dermatologists and researchers continue to have a limited understanding of the vitiligo disease activity signs. The primary goal of this study was to identify \u2018hot spots\u2019 of disease activity signs in vitiligo patients in order to improve detection in clinical practice. Furthermore, the prevalence, clinical profiles of predisposed patients, interrelationship between the disease activity signs and potential pitfalls in the recognition of the signs were evaluated. The Vitiligo Signs of Activity Score (VSAS) was used to score the presence of the disease activity signs in 441 non\u2010segmental and 57 segmental vitiligo patients. More detailed predilection areas were scored in a subset of patients, using 65 predefined body locations. At least one disease activity sign was observed in 51.0% and 8.8% of the non\u2010segmental and segmental vitiligo patients, respectively. Confetti\u2010like depigmentation was most observed on the elbows, Koebner phenomenon on the back of the hands, and hypochromic areas\/borders in the armpits. The three signs were significantly more observed in patients with more involved body locations. Moreover, hypochromic areas\/borders were more common in younger patients. Confetti\u2010like depigmentation had the highest interrelationship with the other signs and was the easiest to recognise. Knowledge around hot spots of the disease activity signs will enhance and simplify their detection in clinical practice. Based on the results, confetti\u2010like depigmentation appears to be the most straightforward sign to evaluate.<\/jats:p>","DOI":"10.1111\/exd.14975","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T13:09:07Z","timestamp":1700226547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hot spots for clinical signs of disease activity in vitiligo"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4589-4381","authenticated-orcid":false,"given":"Liesbeth","family":"Delbaere","sequence":"first","affiliation":[{"name":"Department of Dermatology Ghent University Hospital  Ghent Belgium"},{"name":"Faculty of Medicine and Health Sciences Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"van Causenbroeck","sequence":"additional","affiliation":[{"name":"Department of Dermatology AZ Sint\u2010Lucas  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5260-0986","authenticated-orcid":false,"given":"Jolien","family":"Duponselle","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ghent University Hospital  Ghent Belgium"},{"name":"Faculty of Medicine and Health Sciences Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Van\u00a0Goethem","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9421-3546","authenticated-orcid":false,"given":"Reinhart","family":"Speeckaert","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ghent University Hospital  Ghent Belgium"},{"name":"Faculty of Medicine and Health Sciences Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3249-8195","authenticated-orcid":false,"given":"Nanja","family":"van Geel","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ghent University Hospital  Ghent Belgium"},{"name":"Faculty of Medicine and Health Sciences Ghent University  Ghent 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