{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:05:43Z","timestamp":1790892343225,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Although a large number of existing studies have confirmed that people with vitiligo are prone to mental disorders, these observational studies may be subject to confounding factors and reverse causality, so the true causal relationship is inconclusive. We conducted a bidirectional Mendelian randomization (MR) analysis to assess the causality between vitiligo and mental disorders, namely depression, anxiety, insomnia, schizophrenia, bipolar disorder, obsessive\u2010compulsive disorder (OCD) and attention\u2010deficit hyperactivity disorder (ADHD). Summary statistics from large available genome\u2010wide association study (GWAS) datasets for generalized vitiligo (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200944\u2009266), depression (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009173\u2009005), anxiety (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200917\u2009310), insomnia (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009386\u2009988), schizophrenia (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009130\u2009644), bipolar disorder (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009413\u2009466), OCD (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099725) and ADHD (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009225\u2009534) were utilized. Inverse\u2010variance weighted (IVW), MR\u2010Egger and weighted median were employed to estimate causal effects. Sensitivity analysis and MR Pleiotropy Residual Sum and Outliers (MR PRESSO) were conducted to assess heterogeneity and pleiotropy, ensuring the robustness of the results. Additionally, we corrected for estimating bias that might be brought on by sample overlap using MRlap. In our findings, none of the rigorous bidirectional MR analyses uncovered a significant causal association. Even after applying the MRlap correction, the effect sizes remained statistically nonsignificant, thereby reinforcing the conclusions drawn via IVW. In summary, our genetic\u2010level investigation did not reveal a causal link between generalized vitiligo and mental disorders.\n                  <\/jats:p>","DOI":"10.1111\/exd.14979","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T22:49:30Z","timestamp":1700261370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exploring genetic associations between vitiligo and mental disorders using Mendelian randomization"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0570-6585","authenticated-orcid":false,"given":"Yingwei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou 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