{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T22:34:26Z","timestamp":1761172466930,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Vitamin D deficiency has been reported to be associated with allergic diseases and dermatological disorders. We investigated the role of vitamin D in drug\u2010induced non\u2010immediate hypersensitivity reactions by measuring serum vitamin D levels in 60 patients diagnosed with non\u2010immediate drug hypersensitivity reactions and in 60 patients who tolerated the same medication without any allergic reactions. The results showed that serum vitamin D levels were significantly lower in patients with severe cutaneous adverse reactions (SCARs) (13.56\u2009\u00b1\u20096.23\u2009ng\/mL) compared to patients with mild reactions (17.50\u2009\u00b1\u20097.49\u2009ng\/mL) and the drug\u2010tolerant control group (17.42\u2009\u00b1\u20097.28\u2009ng\/mL), with\n                    <jats:italic>p<\/jats:italic>\n                    values of 0.031 and 0.015, respectively. The proportion of severe vitamin D deficiency (&lt;\u200910\u2009ng\/mL) was much higher in SCAR patients compared to drug\u2010tolerant subjects (36.7% vs. 11.7%,\n                    <jats:italic>p<\/jats:italic>\n                    value\u2009=\u20090.005). After adjusting for age, gender, region of residence, and concurrent illnesses, patients with severe vitamin D deficiency had significantly increased in\u2010hospital mortality (odds ratio 16.04; 95% CI, 1.25\u2013206.12,\n                    <jats:italic>p<\/jats:italic>\n                    value\u2009=\u20090.03). In conclusion, the risk of developing SCARs and in\u2010hospital mortality was increased in patients with severe vitamin D deficiency. Further investigations should be conducted to elucidate the role of vitamin D in the development of SCARs.\n                  <\/jats:p>","DOI":"10.1111\/exd.14980","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T14:09:15Z","timestamp":1700057355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Severe vitamin D deficiency increases the risk of severe cutaneous adverse reactions"],"prefix":"10.1111","volume":"33","author":[{"given":"Natthiya","family":"Pholmoo","sequence":"first","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Department of medicine, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7837-8263","authenticated-orcid":false,"given":"Supitchaya","family":"Thaiwat","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Dermatology Phramongkutklao Hospital  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6063-2403","authenticated-orcid":false,"given":"Jettanong","family":"Klaewsongkram","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Department of medicine, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society  Bangkok Thailand"},{"name":"The Skin and Allergy Research Unit Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0000000000000360"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.799709"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12040988"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2012-1000"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0225402"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2011.205"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e318214ea2d"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nbu.12349"},{"issue":"1","key":"e_1_2_10_10_1","first-page":"48","article-title":"Vitamin D deficiency in Thailand","volume":"2","author":"Siwamogsatham 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